Pregnancy Outcomes Among Women with Homozygous Hemoglobin E Disease: A Retrospective Cohort Study

Maternal and Child Health Journal
Supatra SirichotiyakulTheera Tongsong

Abstract

Background Homozygous hemoglobin E (HbE) disease is common, especially in Southeast Asia where the prevalence may be as high as nearly 1 % of pregnancies and it is usually associated with mild anemia. Nevertheless, the effects of the disease on pregnancy outcomes have never been explored. Objective To compare the obstetric adverse outcomes between singleton pregnancies complicated with HbE disease and normal controls. Patients and Methods A retrospective cohort study was undertaken by assessment of the database of maternal-fetal medicine units, Chiang Mai University, Thailand, from January 2000 to December 2014 to search for the records of pregnant women complicated by the disease. The records of low risk pregnancies were randomly selected as a control group with a ratio of 10:1. Pregnancies with underlying medical diseases or fetal abnormalities as well as those with no complete data were excluded. Result During the study period, 78 women with homozygous HbE disease (study group) and 780 normal controls were recruited. Most baseline characteristics of the two groups were similar. The mean birth weight was significantly lower in the study group (2683 ± 627 vs 2925 ± 623 g, P = 0.001).The prevalence of fetal growth restriction w...Continue Reading

References

Jan 1, 1987·Hemoglobin·S Fucharoen, P Winichagoon
Sep 26, 2008·Archives of Gynecology and Obstetrics·Kuntharee TraisrisilpTheera Tongsong
Nov 26, 2008·International Journal of Gynaecology and Obstetrics : the Official Organ of the International Federation of Gynaecology and Obstetrics·Theera TongsongSuchaya Luewan
Dec 17, 2008·International Journal of Gynaecology and Obstetrics : the Official Organ of the International Federation of Gynaecology and Obstetrics·Suchaya LuewanTheera Tongsong
Oct 16, 2010·International Journal of Clinical Practice·S M P J JansA L M Lagro-Janssen
Aug 22, 2012·Cold Spring Harbor Perspectives in Medicine·Suthat Fucharoen, David J Weatherall
May 18, 2013·Archives of Gynecology and Obstetrics·Tharangrut HanprasertpongSavitree Pranpanus

Related Concepts

Fetal Growth Retardation
Hemoglobin E
Low Birth Weight Infant
Pregnancy Complications, Hematologic
Pregnancy Outcome
Retrospective Studies
Nested Case-Control Studies
Thalassemia Minor
Premature Birth
Anemia

Related Feeds

Anemia

Anemia develops when your blood lacks enough healthy red blood cells. Anemia of inflammation (AI, also called anemia of chronic disease) is a common, typically normocytic, normochromic anemia that is caused by an underlying inflammatory disease. Here is the latest research on anemia.

Related Papers

Archives of Gynecology and Obstetrics
Chitrakan CharoenboonTheera Tongsong
The Journal of Maternal-fetal & Neonatal Medicine : the Official Journal of the European Association of Perinatal Medicine, the Federation of Asia and Oceania Perinatal Societies, the International Society of Perinatal Obstetricians
Walairat KemthongTheera Tongsong
Journal of the Medical Association of Thailand = Chotmaihet Thangphaet
Kuntharee Traisrisilp, Theera Tongsong
© 2021 Meta ULC. All rights reserved