Pregnancy outcomes among women with systemic lupus erythematosus: a retrospective cohort study from Thailand

Lupus
S PhanseneeTheera Tongsong

Abstract

Objective The objective of this paper is to compare adverse pregnancy outcomes between normal pregnancies and pregnancies with systemic lupus erythematosus (SLE), particularly focusing on uncomplicated SLE with remission. Methods A retrospective cohort study was conducted by accessing the Maternal-Fetal Medicine (MFM) Unit database and the full medical records of the women. The records of singleton pregnancies with SLE and no underlying disease were assigned as the study group and their medical records were reviewed. The low-risk pregnancies were randomly selected as the controls. The adverse pregnancy outcomes were compared between the control group vs women with SLE, control group vs uncomplicated SLE, and between the subgroups within the study group. Results Of 28,003 births during the study period, 1400 controls and 140 pregnancies with SLE were compared. The rates of fetal loss, preterm birth, small-for-date, low birth weight and preeclampsia were significantly higher in the study groups with a relative risk of 5.6 (95% CI: 2.9-10.9), 3.2 (95% CI: 2.5-4.1), 3.5 (95% CI: 2.4-4.9), 4.2 (95% CI: 3.4-5.3) and 2.9 (95% CI: 1.9-4.4), respectively. The increased rates of most adverse outcomes were still noted even in the cases of...Continue Reading

References

Oct 1, 1993·Arthritis and Rheumatism·M B UrowitzJ McDonald
Jul 10, 2003·Autoimmunity Reviews·Ricard CerveraJuan Balasch
May 5, 2016·European Journal of Internal Medicine·Gabriella Moroni, Claudio Ponticelli

Citations

Jan 15, 2018·Journal of the American Heart Association·Sandra A HartasanchezMartin Lajous
Sep 26, 2019·Hormone Molecular Biology and Clinical Investigation·Aida KalokMohamad Nasir Shafiee
Aug 3, 2020·BJOG : an International Journal of Obstetrics and Gynaecology·K J GrayR Saxena
Sep 19, 2018·Nature Reviews. Nephrology·Norberto PericoGiuseppe Remuzzi
Jul 29, 2019·Clinical Rheumatology·Elham RajaeiZeinab Deris Zayeri
Apr 1, 2020·International Journal of Rheumatic Diseases·Miguel A SaavedraLuis J Jara

Methods Mentioned

BETA
cesarean section

Related Concepts

Lupus Erythematosus, Systemic
Pregnancy Complications
Pregnancy Outcome
Retrospective Studies
Hypertensive Disease
Lupus Nephritis
Pre-Eclampsia
Woman
Antiphospholipid Syndrome
Fetal Blood Loss

Related Feeds

Antiphospholipid Syndrome

Antiphospholipid syndrome or antiphospholipid antibody syndrome (APS or APLS), is an autoimmune, hypercoagulable state caused by the presence of antibodies directed against phospholipids.

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