Pregnancy outcomes and infant growth among babies with in-utero exposure to tenofovir-based preexposure prophylaxis for HIV prevention

AIDS
Renee HeffronPartners Demonstration Project and the Partners PrEP Study Teams

Abstract

Global guidelines recommend preexposure prophylaxis (PrEP) use by women at risk for HIV, including during pregnancy, a period with heightened HIV risk. However, data to support safety of PrEP use during pregnancy are limited, particularly from women using PrEP throughout pregnancy. In an open-label delivery study of PrEP integrated with ART for high-risk HIV serodiscordant couples in Kenya and Uganda (the Partners Demonstration Project), women who became pregnant while using PrEP were offered the option to continue PrEP throughout pregnancy. We compared pregnancy outcomes and 1-year infant growth from pregnancies with exposure to PrEP throughout pregnancy to those without any exposure, with data from the placebo arm of a prior efficacy trial of PrEP conducted in the same setting. Outcomes from 30 women who elected to continue PrEP throughout pregnancy were compared with those from 96 pregnancies among PrEP-unexposed women. There were small nonsignificant decreases in the frequency of pregnancy loss [16.7% PrEP-exposed versus 23.5% PrEP-unexposed, adjusted odds ratio (aOR) = 0.59, P = 0.4] and preterm delivery [0 versus 7.7%, (aOR) = 0.54, exact P = 0.6]. No congenital anomalies occurred among PrEP-exposed infants. PrEP-exposed ...Continue Reading

References

Feb 15, 2007·European Journal of Clinical Nutrition·T R Fenton, R S Sauve
Jul 26, 2011·AIDS·Nelly R MugoUNKNOWN Partners in Prevention HSV/HIV Transmission Study Team
Mar 3, 2012·AIDS·George K SiberryUNKNOWN Pediatric HIV/AIDS Cohort Study (PHACS)
Jul 13, 2012·The New England Journal of Medicine·Jared M BaetenUNKNOWN Partners PrEP Study Team
Nov 29, 2012·Journal of Acquired Immune Deficiency Syndromes : JAIDS·Erin M KahleUNKNOWN Partners in Prevention HSVHIV Transmission Study and the Partners PrEP Study Teams
Jan 30, 2016·Infectious Diseases in Obstetrics and Gynecology·Jillian PintyeChristine J McGrath

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Citations

Oct 30, 2019·Antimicrobial Agents and Chemotherapy·Sigcinile DlaminiJanet P Hapgood
Jan 9, 2020·Journal of the International AIDS Society·Dvora L Joseph DaveyUNKNOWN PrEP in Pregnancy Working Group
Aug 21, 2020·Journal of the International AIDS Society·Benjamin H ChiChewe Luo
May 15, 2020·Nature Medicine·Elizabeth M Irungu, Jared M Baeten
Aug 30, 2019·International Journal of STD & AIDS·David J DiTullioDvora L Joseph Davey
Jan 7, 2021·Prenatal Diagnosis·Kristin Harris, Mark H Yudin
Jul 31, 2021·American Journal of Perinatology·Elisa T BushmanLorie M Harper
Oct 29, 2021·Journal of Acquired Immune Deficiency Syndromes : JAIDS·Helen ReesSinead Delany-Moretlwe

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