Pregnancy outcomes in autosomal dominant polycystic kidney disease: a case-control study

The Journal of Maternal-fetal & Neonatal Medicine : the Official Journal of the European Association of Perinatal Medicine, the Federation of Asia and Oceania Perinatal Societies, the International Society of Perinatal Obstetricians
Min WuCindy A Kermott

Abstract

To determine whether autosomal dominant polycystic kidney disease (ADPKD) is associated with adverse fetal outcomes and maternal complications. We identified a cohort of 146 patients seen for pregnancy and cystic kidney disease at Mayo Clinic from 1975 to 2010. From this cohort, 54 patients met the ultrasound diagnostic criteria for ADPKD (ADPKD group), while the other 92 patients were diagnosed as "Simple Cyst" (control group). We compared the fetal and maternal outcomes of pregnancy and long-term maternal prognoses between these two groups. Overall, the fetal complication rates were similar between the ADPKD and control groups. Rates of spontaneous abortion (15.1% versus 14%, p = 0.77) and premature birth (11.1% versus 6.8%, p = 0.44) were comparable between groups, while the rate of fetal distress (3.4% versus 0.7%, p < 0.01) was increased in the ADPKD group. The rate of preeclampsia in the patients with simple cysts (2%) was similar to that of the general population. In contrast, the pregnant ADPKD patients had higher risks for hypertension, proteinuria, edema, urinary tract infection, renal dysfunction and preeclampsia during their pregnancies. ADPKD is associated with increased maternal complications during pregnancy, but...Continue Reading

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Citations

Jan 23, 2018·Nature Reviews. Nephrology·Kate S WilesKate Bramham
Nov 3, 2016·Current Opinion in Obstetrics & Gynecology·Rosemary Townsend, Asma Khalil
Jun 28, 2018·Journal of Nephrology·Gianfranca CabidduUNKNOWN Kidney and Pregnancy Study Group of the Italian Society of Nephrology
Mar 28, 2020·Nutrients·Pasquale EspositoNovella Evelina Conti
Nov 2, 2019·BMC Nephrology·Kate WilesKate Bramham
Jun 18, 2020·International Journal of Women's Health·Lucy McBrideShilpanjali Jesudason
Jan 24, 2019·Journal of Clinical Medicine·Alejandra Oralia Orozco GuillénMagdalena Madero
Jan 19, 2021·Jornal brasileiro de nefrologia : ʹorgão oficial de Sociedades Brasileira e Latino-Americana de Nefrologia·Inês Filipe GouveiaClaudina Carvalho
Nov 6, 2021·American Journal of Obstetrics and Gynecology·Sukainah Al KhalafAli S Khashan

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