Pregnancy outcomes in patients with vitiligo: A nationwide population-based cohort study from Korea

Journal of the American Academy of Dermatology
Kui Young ParkJung Min Bae

Abstract

Vitiligo is a chronic autoimmune skin disorder affecting 1% of populations worldwide. Few large-scale studies have explored adverse pregnancy outcomes in patients with vitiligo. To investigate adverse pregnancy outcomes in patients with vitiligo. We performed a retrospective cohort study on 4738 pregnancies of women with vitiligo and 47,380 pregnancies of age-matched controls without vitiligo using the Korean National Health Insurance Claims database from 2007 to 2016. Multivariate logistic regression models were used to evaluate the associations between vitiligo and pregnancy outcomes, including live births, spontaneous abortion, cesarean delivery, preterm delivery, gestational diabetes mellitus, stillbirth, pre-eclampsia/eclampsia, and intrauterine growth retardation. Patients with vitiligo exhibited a significantly lower live birth rate (odds ratio, 0.870; 95% confidence interval, 0.816-0.927) and a higher incidence of spontaneous abortion (odds ratio, 1.250; 95% confidence interval, 1.148-1.362) than the control group. The Korean National Health Insurance Claims database lacks detailed clinical information on individual patients. Vitiligo was significantly associated with an increased risk of spontaneous abortion. Further s...Continue Reading

Citations

Mar 9, 2019·Journal of the European Academy of Dermatology and Venereology : JEADV·K S FloodA B Kimball
May 6, 2019·Current Treatment Options in Oncology·Ion G Motofei
Apr 9, 2020·Alimentary Pharmacology & Therapeutics·Han H LeeMyung-Gyu Choi
Sep 11, 2020·Photodermatology, Photoimmunology & Photomedicine·Jung Min BaeChul Jong Park
Aug 4, 2020·Journal of Translational Autoimmunity·Torie C PlowdenSunni L Mumford
Sep 21, 2020·Dermatology : International Journal for Clinical and Investigative Dermatology·Maria Rita NascaGiuseppe Micali

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