Pregnancy outcomes in simultaneous pancreas and kidney transplant recipients: a national French survey study

Transplant International : Official Journal of the European Society for Organ Transplantation
Gabrielle NormandOlivier Thaunat

Abstract

Simultaneous pancreas and kidney transplantation (SPK) is currently the best therapeutic option for patients with type 1 diabetes and terminal renal failure. Renal transplantation restores fertility enabling women to pursue pregnancies. However, scarcity of available data on pregnancy outcomes in SPK impedes fair medical counseling. Medical files of all pregnancies that lasted ≥3 months among recipients of functional SPK performed between 1990 and 2015 in France were retrospectively analyzed. Twenty-six pregnancies in 22 SPK recipients were identified. Main maternal complications included gestational hypertension (53.8%) and infections (50%). Cesarean section was performed in 73% of cases. Overall fetal survival was 92.6% with a mean gestational age of 34.2 ± 3 weeks. Four children (16.7% of live births) had a birth weight <10th percentile. Endocrine pancreas graft function remained stable during pregnancy. An acute kidney rejection occurred in two patients, one of which resulting in graft loss. Kidney and pancreas graft survival was, respectively, 96% and 100% at 1 year postconception and did not differ from controls. Pregnancy in SPK is feasible, but patients should be informed of the risks for the fetus, the mother, and the ...Continue Reading

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Jun 28, 2018·Tissue Engineering. Part B, Reviews·Caden DuffyAlonzo D Cook
Apr 20, 2018·American Journal of Transplantation : Official Journal of the American Society of Transplantation and the American Society of Transplant Surgeons·Michela AssalinoThierry Berney
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Sep 23, 2020·Journal of Nephrology·Amelia CarettoAntonio Secchi
Dec 22, 2021·Zeitschrift für Geburtshilfe und Neonatologie·Zana StanicMarko Lagancic

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