Pregnancy outcomes in women with childhood-onset and adult-onset systemic lupus erythematosus: a comparative study

Rheumatology International
M A SaavedraL J Jara


To compare the maternal and fetal outcomes between childhood-onset and adult-onset systemic lupus erythematosus (SLE), we reviewed the medical records of SLE pregnant women treated from January 2005 to August 2013. For comparison, patients were allocated to one of the two groups, those pregnant patients with SLE onset before 18 years of age (childhood-onset) and ≥18 years (adult-onset). The patients were evaluated at least once in each trimester and postpartum. Relevant maternal and fetal outcomes were extracted, such as lupus flare, preeclampsia/eclampsia, rate of liveborns, fetal loss (spontaneous abortion and stillbirth), term delivery, preterm birth, neonatal death, low birth weight, low birth weight at term, and congenital malformations. We studied 186 pregnancies (in 180 women), 58 of them had childhood-onset SLE, and the remaining 128 had adult-onset SLE. The rate of maternal and fetal complications was similar in both groups. Multivariate analysis showed that active SLE before pregnancy, primigravida, renal flare, preeclampsia, lupus flare, anticardiolipin antibodies, and low serum complement were associated with an increased risk of poor maternal and fetal outcomes. The diagnosis of childhood-onset had no impact on mat...Continue Reading


Feb 5, 2005·Arthritis and Rheumatism·Megan E B ClowseMichelle Petri
Jun 23, 2005·American Journal of Obstetrics and Gynecology·Eliza F ChakravartyMaurice L Druzin
May 15, 2007·Rheumatic Diseases Clinics of North America·Megan E B Clowse
Feb 2, 2008·Arthritis and Rheumatism·Hermine I BrunnerEarl D Silverman
Jun 21, 2008·Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association·Enrico ImbasciatiDaniele Marcelli
Mar 17, 2010·The Journal of Rheumatology·D D GladmanM B Urowitz
Dec 15, 2010·Lupus·N RupertoLupus Foundation of America, Inc. International Flare Consensus Initiative
Apr 14, 2011·Nature Reviews. Rheumatology·Aimee O HershEd Yelin
Jan 27, 2012·Clinical Rheumatology·M A SaavedraL J Jara
Jun 26, 2012·Arthritis Care & Research·Clovis A SilvaHermine I Brunner
Nov 6, 2012·British Journal of Hospital Medicine·Tanya Baqai, Yiannis Ioannou
Nov 19, 2013·Best Practice & Research. Clinical Rheumatology·Clara Malattia, Alberto Martini
Dec 4, 2014·Revista brasileira de ginecologia e obstetrícia : revista da Federação Brasileira das Sociedades de Ginecologia e Obstetrícia·Eduardo Durans FiguerêdoAntônio Augusto Moura da Silva
Jun 23, 2015·Annals of Internal Medicine·Jill P BuyonJane E Salmon


Jun 7, 2019·Current Opinion in Rheumatology·L J JaraM A Saavedra
Aug 17, 2020·Rheumatology International·Cassandra Michele Skinner-TaylorDionicio Angel Galarza-Delgado
Dec 29, 2019·Journal of Obstetrics and Gynaecology Canada : JOGC = Journal D'obstétrique Et Gynécologie Du Canada : JOGC·Line Leduc

Related Concepts

Trending Feeds


Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Hereditary Sensory Autonomic Neuropathy

Hereditary Sensory Autonomic Neuropathies are a group of inherited neurodegenerative disorders characterized clinically by loss of sensation and autonomic dysfunction. Here is the latest research on these neuropathies.

Glut1 Deficiency

Glut1 deficiency, an autosomal dominant, genetic metabolic disorder associated with a deficiency of GLUT1, the protein that transports glucose across the blood brain barrier, is characterized by mental and motor developmental delays and infantile seizures. Follow the latest research on Glut1 deficiency with this feed.

Regulation of Vocal-Motor Plasticity

Dopaminergic projections to the basal ganglia and nucleus accumbens shape the learning and plasticity of motivated behaviors across species including the regulation of vocal-motor plasticity and performance in songbirds. Discover the latest research on the regulation of vocal-motor plasticity here.

Neural Activity: Imaging

Imaging of neural activity in vivo has developed rapidly recently with the advancement of fluorescence microscopy, including new applications using miniaturized microscopes (miniscopes). This feed follows the progress in this growing field.

Nodding Syndrome

Nodding Syndrome is a neurological and epileptiform disorder characterized by psychomotor, mental, and growth retardation. Discover the latest research on Nodding Syndrome here.

LRRK2 & Microtubules

Mutations in the LRRK2 gene are risk-factors for developing Parkinson’s disease (PD). LRRK2 mutations in PD have been shown to enhance its association with microtubules. Here is the latest research.