Pregnancy outcomes in women with or without placental malaria infection

International Journal of Gynaecology and Obstetrics : the Official Organ of the International Federation of Gynaecology and Obstetrics
S N KassamC Sergi

Abstract

To assess delivery outcomes in women with placental malaria who presented at public hospitals in Kisumu, a holoendemic region in western Kenya. A cross-sectional study using both histology and molecular biology was conducted with 90 consecutive pregnant women who presented at 3 hospitals during a 2-week period. Data collectors completed standardized questionnaires using each patient's hospital record and physical examination results, and registered birth indices such as weight, head circumference, and weight-head ratio. Malaria infection of the placenta was assessed using a molecular biology approach (for genomic differences among parasite species) as well as histology techniques. Of the 5 histologic classes of placental infection, class 1 corresponds to active infection and class 4 to past infection; class 2 and 3 to active chronic infection; and class 5 to uninfected individuals. Plasmodium species typing was determined by polymerase chain reaction amplification of the parasite's genome. In newborns at term, low birth weight was directly associated with classes 2 and 4 of placental infection (P = 0.053 and P = 0.003, respectively), and differences in birth weight remained significant between the 5 classes (P < 0.001) even aft...Continue Reading

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Citations

Feb 2, 2013·Journal of Obstetrics and Gynaecology of India·Gita GuinShashi Khare
Dec 15, 2006·Malaria Journal·Frank P MockenhauptUlrich Bienzle
Jan 26, 2013·Mediterranean Journal of Hematology and Infectious Diseases·Ebako Ndip Takem, Umberto D'Alessandro
Jun 23, 2009·Acta Tropica·Ebako Ndip TakemPeter Martins Ndumbe
Dec 31, 2014·The Korean Journal of Parasitology·Loeki Enggar FitriNicole Berens-Riha
Oct 11, 2014·The Journal of Infectious Diseases·Bridget E BarberNicholas M Anstey
Sep 2, 2020·Scientific Reports·Ayansina AyanladeMargaret O Jegede

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