Pregnancy outcomes in women with thalassemia in North America and the United Kingdom

American Journal of Hematology
Alexis ThompsonThalassemia Clinical Research Network

Abstract

Improved survival in thalassemia has refocused attention on quality of life, including family planning. Understanding the issues associated with infertility and adverse pregnancy outcomes may impact clinical care of patients with thalassemia. We report the number and outcomes of pregnancies among subjects enrolled in Thalassemia Clinical Research Network (TCRN) registries and examine variables associated with successful childbirth. We identified 129 pregnancies in 72 women among the 264 women, age 18 years or older in our dataset. Over 70% of pregnancies resulted in live births and 73/83 (88%) of live births occurred at full term. Most pregnancies (78.2%) were conceived without reproductive technologies. Most (59.3%) pregnancies occurred while on chronic transfusion programs, however only 38.9% were on iron chelation. Four women developed heart problems. Iron burden in women who had conceived was not significantly different from age- and diagnosis-matched controls that had never been pregnant. There was also no difference in pregnancy outcomes associated with diagnosis, transfusion status, diabetes or Hepatitis C infection. Pregnancies occurred in 27.3% of women with thalassemia of child-bearing age in the TCRN registries, a no...Continue Reading

References

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Citations

Aug 21, 2015·Archives of Disease in Childhood·Ali AmidRobert J Klaassen
Jun 7, 2015·Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association·Giorgina Barbara Piccoli'Kidney and Pregnancy Study Group' of the 'Italian Society of Nephrology'
Jun 11, 2017·Journal of Obstetrics and Gynaecology : the Journal of the Institute of Obstetrics and Gynaecology·Kuntharee TraisrisilpTheera Tongsong
Oct 11, 2017·Acta Haematologica·Claudio FozzaRoberto Antonucci
Aug 2, 2019·Journal of Pediatric Hematology/oncology·Taylor RadkeLisa Feuchtbaum

Related Concepts

Blood Transfusion
Health Status
Iron
Iron Chelating Agents
Thalassemia Minor
Assisted Reproductive Technologies
Stillbirth
Birth
Diabetes
Infertility

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