Pregnancy outcomes of Q fever: prospective follow-up study on Reunion island

BMC Infectious Diseases
Yoan MboussouPatrick Gérardin

Abstract

Q fever has been associated with perinatal complications. We conducted a prospective follow-up study to assess both the incidence of adverse pregnancy outcomes (APOs) associated with Coxiella burnetii infection and the contribution of Q fever to APOs. Between May 1 and October 31, 2013, within the regional perinatal health care centre of Saint Pierre, Reunion island, we investigated unexplained miscarriages, stillbirths, preterm births or small-for-gestational age children. Seropositivity for C. burnetii antibodies was defined using indirect immunofluorescence for a phase 2 IgG titre ≥1:64. Acute Q fever was defined for a high phase 2 IgG titre ≥1:256 (compatible with recent or active infection) or the detection of C. burnetii genome in miscarriage products and placentas. Incidence rate ratios (IRR) for Q fever related APOs (taken as a composite outcome or individually) were assessed using Poisson regression models for dichotomous outcomes controlling major confounders. Over a 6-month period, 179 pregnant women suspected or diagnosed with an APO were investigated for Q fever, of whom 118 met the definition for an APO. Of these, 19 were seropositive and 10 presented a profile indicative of an acute infection. For three women wit...Continue Reading

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Citations

Apr 5, 2020·BMC Infectious Diseases·Julien JaubertPatrick Gérardin
Apr 6, 2020·Best Practice & Research. Clinical Obstetrics & Gynaecology·Hong ZhaoYi-Hua Zhou
Aug 15, 2021·BMJ Case Reports·Maxwell BraddickSuji Prabhaharan

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Methods Mentioned

BETA
PCR
PCRs

Software Mentioned

Stata
Primer Express

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