Pregnancy preserves pulmonary function following influenza virus infection in C57BL/6 mice

American Journal of Physiology. Lung Cellular and Molecular Physiology
Meghan S VermillionSabra L Klein

Abstract

Pregnancy is associated with significant anatomic and functional changes to the cardiopulmonary system. Using pregnant C57BL/6 mice, we characterized changes in pulmonary structure and function during pregnancy in healthy animals and following infection with influenza A virus (IAV). We hypothesized that pregnancy-associated alterations in pulmonary physiology would contribute to the more severe outcome of IAV infection. Nonpregnant and pregnant females (at embryonic day 10.5) were either mock-infected or infected with 2009 H1N1 IAV for assessment of pulmonary function, structure, and inflammation at 8 days postinoculation. There were baseline differences in pulmonary function, with pregnant females having greater lung compliance, total lung capacity, and fixed lung volume than nonpregnant females. Following IAV infection, both pregnant and nonpregnant females exhibited reduced circulating progesterone, which in nonpregnant females was associated with increased pulmonary resistance and decreased lung compliance, minute ventilation, and oxygen diffusing capacity compared with uninfected nonpregnant females. In pregnant females, reduced concentrations of progesterone were associated with adverse pregnancy outcomes, but measures of...Continue Reading

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Citations

Dec 25, 2019·Cold Spring Harbor Perspectives in Medicine·Rebekah HonceStacey Schultz-Cherry
Oct 30, 2020·Journal of Virology·Anna ChudnovetsIrina Burd
Apr 7, 2021·American Journal of Physiology. Lung Cellular and Molecular Physiology·Lennart K A Lundblad, Annette Robichaud
Aug 7, 2021·Vaccines·Ericka Kirkpatrick Roubidoux, Stacey Schultz-Cherry

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Methods Mentioned

BETA
flow cytometry

Software Mentioned

GraphPad Prism
FlowJo
FACSDiva

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