Pregnancy rates for single embryo transfer (SET) of day 5 and day 6 blastocysts after cryopreservation by vitrification and slow freeze

Journal of Assisted Reproduction and Genetics
Leah KayeLawrence Engmann

Abstract

The purpose of this study was to compare clinical and ongoing pregnancy rates in cycles with single embryo transfer (SET) of blastocysts cryopreserved on day 5 or day 6. Our aim was to determine whether day 6 blastocysts perform adequately to recommend SET. Retrospective cohort study including 468 transfer cycles for 392 women younger than age 38 undergoing SET at a university-affiliated IVF clinic in the USA. A total of 261 day 5 blastocysts and 207 day 6 blastocysts for frozen-thawed SET between 2010 and 2016 were analyzed. Data included cryopreservation by both a slow freeze method and vitrification. In total, 59.0% of day 5 SET cycles resulted in a clinical pregnancy compared to 54.1% of day 6 blastocysts (p = 0.54). Ongoing pregnancy rates from day 5 frozen-thawed blastocysts (51.7%) were comparable to day 6 (44.9%, p = 0.14). When looking at vitrified blastocysts only, there were no significant differences between day 5 and day 6 blastocysts, with a clinical pregnancy rate of 69.2% for day 5 and 72.5% for day 6 (p = 0.68). SETs of day 6 cryopreserved blastocysts resulted in similar clinical and ongoing pregnancy rates compared to day 5, particularly after vitrification.

References

Jun 16, 1999·Current Opinion in Obstetrics & Gynecology·D K Gardner, W B Schoolcraft
Jun 17, 2000·Fertility and Sterility·D K GardnerW B Schoolcraft
Apr 9, 2002·Fertility and Sterility·Barry BehrAmin A Milki
Mar 24, 2004·Fertility and Sterility·David K GardnerWilliam B Schoolcraft
Dec 3, 2004·The New England Journal of Medicine·Ann ThurinChristina Bergh
Jan 8, 2008·Fertility and Sterility·Eric D LevensFrederick W Larsen
Jun 12, 2010·Fertility and Sterility·Samer AlfarawatiDagan Wells
Sep 8, 2011·BJOG : an International Journal of Obstetrics and Gynaecology·T El-ToukhyP Braude
Jul 14, 2012·Fertility and Sterility·Lindsay KroenerDavid Hill
Oct 26, 2012·Fertility and Sterility·UNKNOWN Practice Committee of American Society for Reproductive Medicine, UNKNOWN Practice Committee of Society for Assisted Reproductive Technology
Jul 1, 2016·Clinical and Experimental Reproductive Medicine·Yong Soo HurJin Ho Lim
Oct 8, 2016·Journal of Assisted Reproduction and Genetics·Jigal HaasKen Cadesky

❮ Previous
Next ❯

Citations

Dec 6, 2017·Journal of Assisted Reproduction and Genetics·Alice TubbingCandice Autin
Aug 16, 2019·Zygote : the Biology of Gametes and Early Embryos·Romualdo SciorioSusan J Pickering
Feb 6, 2020·The Journal of Obstetrics and Gynaecology Research·Yi-Xin LiDang-Xia Zhou
Aug 15, 2020·Journal of Human Reproductive Sciences·Parnita SardanaManish Banker
Jun 30, 2019·Zygote : the Biology of Gametes and Early Embryos·D MontjeanP Boyer
Jun 17, 2020·Human Fertility : Journal of the British Fertility Society·Caizhu WangHong Zhou
Mar 9, 2020·European Journal of Obstetrics, Gynecology, and Reproductive Biology·MeiFang ZengJinLiang Duan
Apr 1, 2021·Reproductive Biomedicine Online·Aila CoelloAna Cobo

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.