Pregnancy-related thrombosis in a woman with congenital afibrinogenemia: a report of two successful pregnancies

American Journal of Hematology
H RoquéD Hart

Abstract

We managed two pregnancies in a woman with congenital afibrinogenemia with increasing amounts of cryoprecipitate to achieve a pre-infusion fibrinogen level of 60 mg/dL. The first pregnancy resulted in placental abruption at 36 weeks, in spite of recent cryoprecipitate infusion. Both placentas showed infarction. Post-partum ovarian and renal vein thromboses complicated the second pregnancy. Mean FVIII (344%) and vWF Antigen (323%) were elevated prior to cryoprecipitate infusion, with mean post-infusion levels of 367% and 363%. The clearance of fibrinogen after cryoprecipitate infusion increased during the course of pregnancy. A paradoxical prothrombotic state with embolization may play a role in the observed complications of pregnancy.

References

Jul 1, 1991·British Journal of Obstetrics and Gynaecology·A K Trehan, I L Fergusson
Dec 1, 1985·American Journal of Obstetrics and Gynecology·Y Inamoto, T Terao
Jan 1, 1996·Gynecologic and Obstetric Investigation·T KobayashiT Terao
Oct 16, 1999·British Journal of Haematology·M LakP M Mannucci
Jun 10, 2000·British Journal of Haematology·T KobayashiT Terao
Dec 21, 2000·Haemophilia : the Official Journal of the World Federation of Hemophilia·R ParameswaranB T Colvin
Apr 13, 2001·European Journal of Obstetrics, Gynecology, and Reproductive Biology·T K Eskes
Mar 14, 2002·The American Journal of Pathology·Takayuki IwakiFrancis J Castellino
Feb 13, 2003·Nature Medicine·Berend IsermannHartmut Weiler

❮ Previous
Next ❯

Citations

Mar 15, 2006·Digestive Diseases and Sciences·Nevin OrucTankut Ilter
Oct 24, 2009·Vascular Health and Risk Management·Konstantinos TziomalosVassilia Garipidou
Jun 21, 2014·Heart Views : the Official Journal of the Gulf Heart Association·Soumya PatraC N Manjunath
Jun 14, 2008·Expert Opinion on Biological Therapy·Philippe de Moerloose, Marguerite Neerman-Arbez
Oct 29, 2015·Clinical and Experimental Pharmacology & Physiology·Jingyi ZhouXuefeng Wang
Dec 30, 2015·Journal of Thrombosis and Thrombolysis·Amihai RottenstreichYosef Kalish
Mar 30, 2011·Hematology/oncology Clinics of North America·Gillian N Pike, Paula H B Bolton-Maggs
Apr 19, 2011·Thrombosis Research·Yoann ChevalierClaude Négrier
Oct 12, 2010·Journal of Pediatric and Adolescent Gynecology·Andra H James
Jun 30, 2009·Journal of Stroke and Cerebrovascular Diseases : the Official Journal of National Stroke Association·Demet Funda BasMehmet Akif Topcuoglu
Mar 21, 2009·Haemophilia : the Official Journal of the World Federation of Hemophilia·R KadirP Bolton-Maggs
Jan 11, 2007·Haemophilia : the Official Journal of the World Federation of Hemophilia·J H PayneM Makris
Oct 7, 2008·The Journal of Obstetrics and Gynaecology Research·Ikue MatsushitaNorio Wake
Jun 30, 2011·Journal of Thrombosis and Haemostasis : JTH·L BornikovaM J Manco-Johnson
Jul 16, 2010·Haemophilia : the Official Journal of the World Federation of Hemophilia·A H James
Nov 13, 2009·Haemophilia : the Official Journal of the World Federation of Hemophilia·T Todd, D J Perry
Dec 5, 2014·Haemophilia : the Official Journal of the World Federation of Hemophilia·A LebretonP de Moerloose
Apr 28, 2017·BJOG : an International Journal of Obstetrics and Gynaecology
Feb 2, 2018·Haemophilia : the Official Journal of the World Federation of Hemophilia·M KarimiJ Gerdabi
Apr 16, 2015·American Journal of Clinical Pathology·Alfiya MukaddamShrimati Shetty
Oct 13, 2006·American Journal of Hematology·E Aygören-PürsünW Kreuz
Apr 5, 2008·Blood Coagulation & Fibrinolysis : an International Journal in Haemostasis and Thrombosis·Ismail SimsekMeyer Michel Samama
Jul 14, 2005·Haemophilia : the Official Journal of the World Federation of Hemophilia·A H James
Aug 2, 2019·Haemophilia : the Official Journal of the World Federation of Hemophilia·Vivian ValitonAlessandro Casini
Jun 14, 2016·Expert Review of Hematology·Lucia StanciakovaJan Stasko
Feb 29, 2020·Research and Practice in Thrombosis and Haemostasis·Joline L SaesSaskia E M Schols
Apr 3, 2020·Clinical and Applied Thrombosis/hemostasis : Official Journal of the International Academy of Clinical and Applied Thrombosis/Hemostasis·Yan ZhangYue Teng
Aug 10, 2012·Blood Coagulation & Fibrinolysis : an International Journal in Haemostasis and Thrombosis·Maria KaparouKalliopi Foundouli
Jun 22, 2021·Journal of Obstetrics and Gynaecology of India·Athulya ShajanSiju V Abraham

❮ Previous
Next ❯

Related Concepts

Related Feeds

Autoimmune Thyroiditis

Autoimmune thyroiditis is an inflammatory disease of thyroid gland due to autoimmune responses leading to lymphocytic infiltration of the gland. It is characterized by the presence of circulating thyroid antigen-specific T-cells and thyroid autoantibodies. Discover the latest research on autoimmune thyroiditis here.

© 2022 Meta ULC. All rights reserved