PMID: 11327547May 1, 2001Paper

Pregnancy-specific glycoproteins function as immunomodulators by inducing secretion of IL-10, IL-6 and TGF-beta1 by human monocytes

American Journal of Reproductive Immunology : AJRI
S K SnyderGabriela Dveksler

Abstract

Low levels of pregnancy-specific glycoproteins (PSGs) in maternal serum have been correlated with complications of pregnancy. We investigated the ability of human PSGs to regulate in vitro production of cytokines. Human monocytes and murine RAW 264.7 cells were treated with recombinant PSG1, PSG6, PSG11, or a truncated PSG6 consisting of only the N-terminal domain (PSG6N). Cytokine production in response to PSG-treatment was measured by ELISA and/or reverse transcriptase-PCR. All PSGs tested induced secretion of interleukin (IL)-10, IL-6 and transforming growth factor (TGF)-beta1 by both human and murine cells, but not IL-1beta, tumor necrosis factor (TNF)-alpha or IL-12. The N-terminal domain of PSG6 was sufficient for induction of monocyte cytokine secretion. Induction of IL-10 and IL-6 was preceded by an increase in the specific mRNAs. PSG1, PSG6, PSG6N, and PSG11 induce dose-dependent secretion of anti-inflammatory cytokines by human monocytes. Human and murine PSGs exhibit cross-species activity. Our results are consistent with a role for PSGs in modulation of the innate immune system.

Citations

Aug 25, 2004·Allergologia et immunopathologia·A Blanco-QuirósAgustín Mayo
Jan 5, 2011·The Journal of Biological Chemistry·Felipe A LisboaGabriela S Dveksler
Jan 24, 2002·The Journal of Experimental Medicine·Roseann WaterhouseGabriela S Dveksler
Oct 22, 2003·The Journal of Experimental Medicine·Louise A KoopmanJack L Strominger
Oct 7, 2003·Molecular Biology of the Cell·Diego A EllermanGabriela S Dveksler
May 15, 2008·Physiological Genomics·Christine RamponPhilippe Huber
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Jul 4, 2003·International Journal of Dermatology·Siba P RaychaudhuriSmriti K Raychaudhuri
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