Pregnancy termination with a high and medium dosage regimen of RU 486

Contraception
D ShoupeI M Spitz

Abstract

Sixty healthy pregnant women who wished to terminate their pregnancy and who were no more than 49 days pregnant were treated with one of three different dose regimens of a synthetic progesterone receptor blocker, RU 486. Serum cortisol was measured to determine the antiglucocorticoid effects of this compound. The high dose but shorter treatment regimen (400 mg/day RU 486 X 4 days or 200 mg/day X 4 days) was associated with a high (greater than 80%) rate of side effects, especially nausea, vomiting, weakness and heavy bleeding and a low rate of success (10%). A group of 50 subjects received the medium dose but longer treatment regimen (100 mg/day X 7 days). This group had less side effects (40-60%) and a 72.3% success rate of complete abortion. The AM cortisol values were significantly elevated in all treatment groups but higher in those receiving the high dose. These values returned to normal one week following cessation of treatment. Medium dose but longer duration (100 mg/day X 7 days) of RU 486 treatment is associated with a higher success rate and less side effects than higher dose therapy administered over a shorter period. There were no predictive indices to determine which subjects would respond successfully. The reason ...Continue Reading

References

Oct 11, 1975·The Journal of Clinical Endocrinology and Metabolism·O A KletzkyD R Mishell

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Citations

Apr 1, 1996·Contraception·T B Koopersmith, D R Mishell
Aug 5, 1993·The New England Journal of Medicine·I M Spitz, C W Bardin
Sep 1, 1993·British Journal of Obstetrics and Gynaecology·K J ThongD T Baird
Jul 1, 1989·American Journal of Obstetrics and Gynecology·C P PuriX R Swamy
Sep 1, 1988·Baillière's Clinical Obstetrics and Gynaecology·M Bygdeman, P F Van Look
Jun 1, 1990·Baillière's Clinical Obstetrics and Gynaecology·L Kovács
Apr 1, 1990·Annals of Medicine·O HeikinheimoP Lähteenmäki
Aug 16, 2000·American Journal of Obstetrics and Gynecology·M D Creinin
Mar 3, 2009·Gynecological Endocrinology : the Official Journal of the International Society of Gynecological Endocrinology·Axelle PintiauxJean-Michel Foidart
Jan 1, 1989·Acta Obstetricia Et Gynecologica Scandinavica. Supplement·M Bygdeman, M L Swahn
Sep 12, 2002·Drug Safety : an International Journal of Medical Toxicology and Drug Experience·Vincenzo De LeoFelice Petraglia
Nov 1, 1993·Contraception·I M Spitz, C W Bardin

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