Pregnancy Trimester-Specific Exposure to Ambient Air Pollution and Child Respiratory Health Outcomes in the First 2 Years of Life: Effect Modification by Maternal Pre-Pregnancy BMI

International Journal of Environmental Research and Public Health
Shu-E SohYap-Seng Chong

Abstract

Prenatal exposure to air pollution is associated with childhood respiratory health; however, no previous studies have examined maternal pre-pregnancy body mass index (BMI) as a potential effect modifier. We investigated whether maternal pre-pregnancy BMI modified the association of trimester-specific air pollution divided into quartiles of exposure (Q1⁻4) on respiratory health in the Growing Up in Singapore towards healthy Outcomes (GUSTO) study (n = 953) in 2-year-old children. For episodes of wheezing, children of overweight/obese mothers and who were exposed to particulate matter less than 2.5 μm (PM2.5) in the first trimester had an adjusted incidence rate ratio (IRR) (95% confidence interval (CI)) of 1.85 (1.23⁻2.78), 1.76 (1.08⁻2.85) and 1.90 (1.10⁻3.27) in quartile (Q) 2⁻4, with reference to Q1. This association is seen in the second trimester for bronchiolitis/bronchitis. The risk of ear infection in the first year of life was associated with exposure to PM2.5 in the first trimester with adjusted Odds Ratio (adjOR) (95% CI) = 7.64 (1.18⁻49.37), 11.37 (1.47⁻87.97) and 8.26 (1.13⁻60.29) for Q2⁻4, and similarly in the second year with adjOR (95% CI) = 3.28 (1.00⁻10.73) and 4.15 (1.05⁻16.36) for Q2⁻3. Prenatal exposure to a...Continue Reading

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References

Nov 25, 1995·Lancet·F T ChewB W Lee
Jul 14, 2000·Respirology : Official Journal of the Asian Pacific Society of Respirology·S C Emmanuel
Jul 4, 2008·The New England Journal of Medicine·Peter D GluckmanKent L Thornburg
Nov 18, 2008·The European Respiratory Journal·P LatzinU Frey
Sep 6, 2011·The Science of the Total Environment·Ana EspluguesCarmen Iñiguez
Aug 6, 2013·International Journal of Epidemiology·Shu-E SohUNKNOWN GUSTO Study Group
Aug 2, 2014·Journal of Developmental Origins of Health and Disease·A de VriesT G M Vrijkotte
Jul 16, 2015·American Journal of Respiratory and Critical Care Medicine·Hsiao-Hsien Leon HsuRosalind J Wright
Jul 30, 2015·Environmental Science. Processes & Impacts·B KhezriR D Webster
Aug 22, 2015·The European Respiratory Journal·Jacobien B EisingCornelis K van der Ent
Jan 28, 2017·Annals of Allergy, Asthma & Immunology : Official Publication of the American College of Allergy, Asthma, & Immunology·Kuo-Tung TangYi-Hsing Chen
Aug 2, 2017·Annals of Allergy, Asthma & Immunology : Official Publication of the American College of Allergy, Asthma, & Immunology·Maria José RosaRosalind J Wright
Aug 18, 2017·Pediatric Pulmonology·Ashley RajappanUNKNOWN Southampton Women's Survey Study Group
Feb 9, 2018·The European Respiratory Journal·Éric LavigneMark Walker

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Citations

Jan 30, 2020·Health Promotion Journal of Australia : Official Journal of Australian Association of Health Promotion Professionals·Gemma Carey
Jan 10, 2020·Paediatric and Perinatal Epidemiology·Reem MasarwaKristian B Filion
May 22, 2020·Environmental Science and Pollution Research International·Wu YanYankai Xia
Jan 28, 2021·Toxicological Sciences : an Official Journal of the Society of Toxicology·Lisa KoshkoMarianna Sadagurski
Mar 30, 2021·Environmental Epidemiology·Lauren G ButtlingJulia M Gohlke
Nov 21, 2020·Environmental Research·Azahara M García-SernaUNKNOWN NELA Study group

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