Pregnancy Zone Protein is Increased in the Alzheimer's Disease Brain and Associates with Senile Plaques

Journal of Alzheimer's Disease : JAD
Diana A T NijholtJohan M Kros

Abstract

Increased levels of pregnancy zone protein (PZP) were found in the serum of persons who later developed Alzheimer's disease (AD) in comparison to controls who remained dementia free. We suggested that this increase is due to brain derived PZP entering the blood stream during the early phase of the disease. Here we investigate the possible involvement of PZP in human AD pathogenesis. We observed increased PZP immunoreactivity in AD postmortem brain cortex compared to non-demented controls. In the AD cortex, PZP immunoreactivity localized to microglial cells that interacted with senile plaques and was occasionally observed in neurons. Our data link the finding of elevated serum PZP levels with the characteristic AD pathology and identify PZP as a novel component in AD.

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Citations

Mar 10, 2019·Proceedings of the National Academy of Sciences of the United States of America·Jordan H CaterAmy R Wyatt
Aug 21, 2019·Oxidative Medicine and Cellular Longevity·Jordan H CaterAmy R Wyatt
May 1, 2021·International Journal of Molecular Sciences·Tânia Soares MartinsAna Gabriela Henriques

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Methods Mentioned

BETA
immunoprecipitation

Software Mentioned

SPSS
BLAST

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