Pregnane glycosides from Leptadenia pyrotechnica

Journal of Natural Products
Giuseppina CioffiNunziatina De Tommasi

Abstract

The whole plant of Leptadenia pyrotechnica afforded 18 new pregnane glycosides (1-18) with sarcostin, 11-hydroxysarcostin, and deacetylmetaplexigenin as the aglycon moieties and acetyl, benzoyl, cinnamoyl, p-coumaroyl, and nicotinoyl ester moieties linked at C-12 and/or C-20 of the aglycon and hexopyranose, 6-deoxy-3-O-methylhexopyranose, and 2,6-dideoxy-3-O-methylhexopyranose sugars linked at C-3 of their aglycon. The structures of these compounds were elucidated by spectroscopic data interpretation and from chemical evidence. The antiproliferative activity of all compounds was evaluated using three continuous murine and human culture cell lines, J774.A1, HEK-293, and WEHI-164. Compounds having deacethylmetaplexigenin as aglycon and a cinnamoyl ester moiety linked at C-12 were the most active constituents.

References

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Aug 13, 2003·Biological & Pharmaceutical Bulletin·Tsuyoshi IkedaToshihiro Nohara
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Citations

Jan 15, 2011·Journal of Nutrition and Metabolism·Soundararajan KamalakkannanMohammad A Akbarsha
Aug 13, 2014·BioMed Research International·Carmela SaturninoFrancesco Puoci
Mar 22, 2016·Journal of Ethnopharmacology·Hafiz Muhammad Farhan RasheedQaiser Jabeen
Jan 25, 2014·Natural Product Research·Jiayu GaoXin Li
Jan 29, 2019·Frontiers in Plant Science·Isaneli Batista Dos SantosMaria Carolina Quecine
Jun 1, 2019·Journal of Natural Products·Fang-Yu YuanXiao-Ning Wang

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