Prehabilitation exercise therapy for cancer: A systematic review and meta-analysis.

Cancer Medicine
Christina M MichaelNicholas G Zaorsky

Abstract

The purpose of this study was to determine the impact of prehabilitation exercise intervention with respect to (1) acceptability, feasibility, and safety; and (2) physical function, measured by 6-minute-walk test (6MWT). PRISMA guidelines were used to systematically search PubMed, Embase, and CINAHL databases evaluating prehabilitation exercise interventions. The inclusion criteria were studies investigating patients who underwent surgery for their cancer and underwent prehabilitation exercise. Guidelines were applied by independent extraction by multiple observers. Data were pooled using a random-effects model. Acceptability, feasibility, and safety rates were calculated. 6MWT (maximum distance a person can walk at their own pace on a hard, flat surface, measured in meters, with longer distance indicative of better performance status) was compared using two arms using the DerSimonian and Laird method. Objective 1. Across 21 studies included in this review, 1564 patients were enrolled, 1371 (87.7%) accepted the trial; of 1371, 1230 (89.7% feasibility) completed the intervention. There was no grade 3+ toxicities. Objective 2. Meta-analysis of five studies demonstrated a statistically significant decrease in 6MWT distance postope...Continue Reading

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