Prehabilitation of complex ventral hernia patients with Botulinum: a systematic review of the quantifiable effects of Botulinum.

Hernia : the Journal of Hernias and Abdominal Wall Surgery
J A WegdamS W Nienhuijs

Abstract

Complex ventral hernia repair (CVHR) encompasses patient optimization, primary fascial closure (PFC), mesh reinforcement and component separation technique (CST), if needed. High rates of complications after CST are still reported. Prehabilitation by managing pre-operative modifiable risk factors, like abdominal wall compliance, possibly reduces these rates. Compliance can be modified by intramuscular injection of Botulinum in the lateral abdominal wall muscles (LAWM). Paralysis leads to elongation of these muscles, which may facilitate PFC and/or prevent CST. Evidence to use Botulinum in hernia patients is scarce and fragmented. An update of evidence for the effect of Botulinum is presented. A multi-database search was conducted for Botulinum studies in ventral hernia patients. A systematic review was performed to describe its primary effect on compliance (LAWM elongation) and secondary effects like PFC ± CST rate, complications and recurrence. 14 studies were included (377 patients) with a HDW of median 12 (10-15) cm. A typical intervention consisted of 200-300 U Botulinum in 3 points per hemi-abdomen under US guidance, > 2 weeks pre-operatively and evaluated by CT just before the operation. The primary effect was a median LA...Continue Reading

References

Feb 7, 2003·The Clinical Journal of Pain·Joseph C Arezzo
Jun 6, 2009·Hernia : the Journal of Hernias and Abdominal Wall Surgery·F E MuysomsA Kingsnorth
Jul 22, 2009·PLoS Medicine·David MoherUNKNOWN PRISMA Group
Sep 23, 2009·World Journal of Surgery·Tomas R Ibarra-HurtadoJosé de Jesús González-Jaime
Jun 15, 2011·Pain Medicine : the Official Journal of the American Academy of Pain Medicine·Dustin SmootHenry Schiller
Sep 25, 2012·Hernia : the Journal of Hernias and Abdominal Wall Surgery·M D ZielinskiD Jenkins
Oct 2, 2013·World Journal of Surgery·Benjamin ZendejasMartin D Zielinski
Jul 26, 2014·Surgical Endoscopy·Noah J SwitzerShahzeer Karmali
Jul 15, 2015·The Journal of Surgical Research·Laurel J BlairB Todd Heniford
Feb 11, 2016·Hernia : the Journal of Hernias and Abdominal Wall Surgery·N N AlamN J Smart
Mar 18, 2016·Critical Care : the Official Journal of the Critical Care Forum·Manu L N G MalbrainRobert Wise
Mar 10, 2017·Journal of Plastic Surgery and Hand Surgery·Jason M WeisslerJohn P Fischer
May 11, 2017·Hernia : the Journal of Hernias and Abdominal Wall Surgery·A Torregrosa-GalludF Carbonell-Tatay
Jul 26, 2017·Plastic and Reconstructive Surgery. Global Open·Sinor SoltanizadehLars N Jorgensen
Aug 16, 2017·American Journal of Surgery·Bram CornetteFrederik Berrevoet
Jun 19, 2018·Clinical, Cosmetic and Investigational Dermatology·Souphiyeh Samizadeh, Koenraad De Boulle
Aug 24, 2018·Plastic and Reconstructive Surgery·Nichole A JoslynJeffrey E Janis
Aug 24, 2018·Plastic and Reconstructive Surgery·Benjamin M MotzB Todd Heniford
Sep 12, 2018·Hernia : the Journal of Hernias and Abdominal Wall Surgery·J DeBordA Montgomery
Dec 13, 2018·Hernia : the Journal of Hernias and Abdominal Wall Surgery·J A WegdamT S de Vries Reilingh
Mar 5, 2019·JSLS : Journal of the Society of Laparoendoscopic Surgeons·Douglas E Ott
Apr 6, 2019·Hernia : the Journal of Hernias and Abdominal Wall Surgery·K E ElstnerN Ibrahim
May 2, 2019·Hernia : the Journal of Hernias and Abdominal Wall Surgery·M Ø NielsenK K Jensen
Jun 10, 2019·Hernia : the Journal of Hernias and Abdominal Wall Surgery·K Slim, D Standaert
Sep 1, 2019·Der Chirurg; Zeitschrift für alle Gebiete der operativen Medizen·G Köhler
Sep 12, 2019·Hernia : the Journal of Hernias and Abdominal Wall Surgery·J A WegdamM P Simons
Dec 21, 2019·Hernia : the Journal of Hernias and Abdominal Wall Surgery·O I Rodriguez-AcevedoN Ibrahim
Mar 11, 2020·Hernia : the Journal of Hernias and Abdominal Wall Surgery·S J ZolinD M Krpata
Mar 18, 2020·Frontiers in Surgery·José Bueno-LledóSalvador Pous-Serrano
May 10, 2020·Updates in Surgery·Vanesa Catalán-GarzaAntonio José Torres-García
Jun 11, 2020·Hernia : the Journal of Hernias and Abdominal Wall Surgery·J Martínez-HoedJ Bueno-Lledó

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Sep 22, 2021·Hernia : the Journal of Hernias and Abdominal Wall Surgery·A S TimmerM A Boermeester

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