Prehospital Advanced Diagnostics and Treatment of Acute Stroke: Protocol for a Controlled Intervention Study

JMIR Research Protocols
Kristi G BacheChristian G Lund

Abstract

Acute ischemic stroke (AIS) is a medical emergency. The outcome is closely linked to the time elapsing from symptom onset to treatment, and seemingly small delays can mean the difference between full recovery and physical and cognitive dysfunction. Recanalization to allow blood to reenter the affected area is most efficient immediately after symptoms occur, and intravenous thrombolysis must be initiated no later than 4.5 hours after the symptom onset. A liable diagnosis is mandatory to administer the appropriate treatment. Prehospital diagnosis and, in cases where contraindications are ruled out, prehospital initiation of intravenous thrombolysis have been shown to significantly decrease the time from alarm to the treatment. The objective of this paper is to investigate the effectiveness of prehospital thrombolysis as measured by (1) time spent from symptom onset to treatment and (2) the number of patients treated within 4.5 hours. In addition, we want to conduct explorative studies. These will include (1) the use of biomarkers for diagnostic and prognostic use where we will collect blood samples from various time points, including the hyperacute phase and (2) the study of magnetic resonance imaging (MRI) images at day 1 to det...Continue Reading

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Citations

Nov 15, 2018·Acta Anaesthesiologica Scandinavica·Karianne LarsenHans Morten Lossius
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Feb 3, 2021·JAMA : the Journal of the American Medical Association·Kristi G Bache, James C Grotta
Apr 24, 2021·European Journal of Neurology : the Official Journal of the European Federation of Neurological Societies·Karianne LarsenKristi G Bache

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Methods Mentioned

BETA
blood drawn
blood collection

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