Prehospital Blood Product Resuscitation for Trauma: A Systematic Review

Shock
Iain M SmithMark J Midwinter

Abstract

Administration of high ratios of plasma to packed red blood cells is a routine practice for in-hospital trauma resuscitation. Military and civilian emergency teams are increasingly carrying prehospital blood products (PHBP) for trauma resuscitation. This study systematically reviewed the clinical literature to determine the extent to which the available evidence supports this practice. Bibliographic databases and other sources were searched to July 2015 using keywords and index terms related to the intervention, setting, and condition. Standard systematic review methodology aimed at minimizing bias was used for study selection, data extraction, and quality assessment (protocol registration CRD42014013794). Synthesis was mainly narrative with random effects model meta-analysis limited to mortality outcomes. No prospective comparative or randomized studies were identified. Sixteen case series and 11 comparative studies were included in the review. Seven studies included mixed populations of trauma and non-trauma patients. Twenty-five of 27 studies provided only very low quality evidence. No association between PHBP and survival was found (OR for mortality: 1.29, 95% CI: 0.84-1.96, P = 0.24). A single study showed improved surviva...Continue Reading

Associated Clinical Trials

References

Oct 27, 1994·The New England Journal of Medicine·W H BickellK L Mattox
Feb 5, 1999·The Journal of Trauma·Y BarkanaA Eldad
Jun 6, 1998·Air Medical Journal·K S Berns, S P Zietlow
Jun 5, 2003·The Journal of Trauma·Debra L MaloneLena M Napolitano
Oct 3, 2009·Archives of Surgery·Nicholas SpoerkeMartin Schreiber
Oct 9, 2009·Current Opinion in Critical Care·Rob Dawes, G O Rhys Thomas
Oct 13, 2009·The Journal of Trauma·Hasan B AlamUNKNOWN Hemostatic Resuscitation Research Group
Feb 23, 2010·International Journal of Surgery·David MoherUNKNOWN PRISMA Group
Sep 17, 2010·Emergency Medicine Journal : EMJ·Philip CalderbankDouglas M Bowley
Oct 20, 2010·Archives of Surgery·Jeffrey L JohnsonAngela Sauaia
Mar 12, 2011·Critical Care : the Official Journal of the Critical Care Forum·Nicola CurrySimon Stanworth
Oct 19, 2011·Archives of Surgery·Jonathan J MorrisonMark J Midwinter
Apr 12, 2012·The Journal of Trauma and Acute Care Surgery·Matthew D NealJason L Sperry
Jun 13, 2012·Prehospital and Disaster Medicine·George L HigginsTania D Strout
Aug 8, 2012·The Journal of Trauma and Acute Care Surgery·Brian D KimScott P Zietlow
Nov 9, 2012·The Journal of Trauma and Acute Care Surgery·Andrew J KerwinUNKNOWN Eastern Association for the Surgery of Trauma Practice Management Guidelines Ad Hoc Committee
Dec 25, 2012·Emergency Medicine Journal : EMJ·Daniel BodnarBenjamin Clarke
Jan 8, 2013·Annals of Surgery·Jonathan J MorrisonTodd E Rasmussen
Mar 21, 2013·Critical Care : the Official Journal of the Critical Care Forum·Peter Brendon SherrenBrian J Burns
May 31, 2013·Journal of the Royal Army Medical Corps·Gareth WildP Lund
Aug 15, 2013·The Journal of Trauma and Acute Care Surgery·Deborah J del JuncoUNKNOWN PROMMTT Study Group
Oct 4, 2013·Shock·Elon GlassbergYitshak Kreiss
Mar 29, 2014·Annals of Surgery·Joshua B BrownUNKNOWN Inflammation and the Host Response to Injury Investigators
Jun 17, 2014·Prehospital Emergency Care : Official Journal of the National Association of EMS Physicians and the National Association of State EMS Directors·John B HolcombCharles E Wade
Aug 28, 2014·The Journal of Trauma and Acute Care Surgery·David J O'ReillyMark J Midwinter
Aug 28, 2014·The Journal of Trauma and Acute Care Surgery·David J O'ReillyHeidi Doughty
Oct 21, 2014·Aviation, Space, and Environmental Medicine·Nicole Powell-DunfordStacy A Shackelford

❮ Previous
Next ❯

Citations

Jun 15, 2016·Shock·Mark G Clemens
Nov 3, 2016·Current Opinion in Critical Care·Henna WongSimon J Stanworth
Nov 9, 2016·Critical Care : the Official Journal of the Critical Care Forum·Conor D A TurnerMarius Rehn
Mar 24, 2017·The Journal of Trauma and Acute Care Surgery·Linda C BenavidesJonathan B Lundy
Apr 7, 2017·The Journal of Trauma and Acute Care Surgery·John B HolcombUNKNOWN PROHS Study Group
Oct 27, 2017·Transfusion Medicine·M RehnD J Lockey
Dec 2, 2017·Transfusion Medicine·I M SmithUNKNOWN RePHILL Trial Collaborators
Oct 24, 2017·Current Opinion in Critical Care·Jakob StensballePär I Johansson
Dec 12, 2018·European Journal of Emergency Medicine : Official Journal of the European Society for Emergency Medicine·Joanna E OakeshottUNKNOWN Kent Surrey Sussex Air Ambulance Trust
May 8, 2020·Transfusion Medicine·Heidi Doughty, David Naumann
May 16, 2020·Prehospital Emergency Care : Official Journal of the National Association of EMS Physicians and the National Association of State EMS Directors·Sophie ShandBrian Burns
Jan 7, 2020·Transfusion Medicine·Elisabeth C van TurenhoutPatrick Schober
Aug 17, 2020·Scandinavian Journal of Trauma, Resuscitation and Emergency Medicine·Karl-Christian ThiesBenoît Vivien
Mar 27, 2020·Military Medical Research·Henry T Peng
Nov 21, 2018·Scandinavian Journal of Trauma, Resuscitation and Emergency Medicine·J E GriggsUNKNOWN Kent, Surrey & Sussex Air Ambulance Trust
Mar 1, 2019·World Journal of Emergency Surgery : WJES·Federico CoccoliniFausto Catena
Oct 22, 2020·CJEM·Russell D MacDonald, Aliya Ramjaun
Sep 9, 2020·Vox Sanguinis·Arnaud CassignolJulien Bordes

❮ Previous
Next ❯

Software Mentioned

GRADE
EMBASE
Review Manager
R

Related Concepts

Related Feeds

Blood Clotting Disorders

Thrombophilia includes conditions with increased tendency for excessive blood clotting. Blood clotting occurs when the body has insufficient amounts of specialized proteins that make blood clot and stop bleeding. Here is the latest research on blood clotting disorders.