Prehospital initiation of tirofiban in patients with ST-elevation myocardial infarction undergoing primary angioplasty (On-TIME 2): a multicentre, double-blind, randomised controlled trial

Lancet
A W J van't HofOngoing Tirofiban In Myocardial infarction Evaluation (On-TIME) 2 study group

Abstract

The most effective magnitude and timing of antiplatelet therapy is important in patients with acute ST-elevation myocardial infarction (STEMI). We investigated whether the results of primary coronary angioplasty (PCI) can be improved by the early administration of the glycoprotein IIb/IIIa blocker tirofiban at first medical contact in the ambulance or referral centre. We undertook a double-blind, randomised, placebo-controlled trial in 24 centres in the Netherlands, Germany, and Belgium. Between June 29, 2006, and Nov 13, 2007, 984 patients with STEMI who were candidates to undergo PCI were randomly assigned to either high-bolus dose tirofiban (n=491) or placebo (N=493) in addition to aspirin (500 mg), heparin (5000 IU), and clopidogrel (600 mg). Randomisation was by blinded sealed kits with study drug, in blocks of four. The primary endpoint was the extent of residual ST-segment deviation 1 h after PCI. Analysis was by intention to treat. The trial is registered, number ISRCTN06195297. 936 (95%) patients were randomly assigned to treatment after a prehospital diagnosis of myocardial infarction in the ambulance. Median time from onset of symptoms to diagnosis was 76 min (IQR 35-150). Mean residual ST deviation before PCI (10.9 ...Continue Reading

References

Mar 11, 1993·The New England Journal of Medicine·F ZijlstraH Suryapranata
Dec 14, 2002·The American Journal of Cardiology·David J SchneiderPeter M DiBattiste
Aug 11, 2006·International Journal of Cardiology·Giuseppe De LucaUNKNOWN Ongoing Tirofiban In Myocardial Infarction Evaluation (On-TIME) study group
Oct 13, 2006·JAMA : the Journal of the American Medical Association·Ulf StenestrandUNKNOWN RIKS-HIA Registry
Feb 8, 2008·The New England Journal of Medicine·Tone SvilaasFelix Zijlstra
May 6, 2008·Thrombosis Research·Antonius A C M HeestermansJurriën M ten Berg
May 24, 2008·The New England Journal of Medicine·Stephen G EllisUNKNOWN FINESSE Investigators
May 24, 2008·The New England Journal of Medicine·Gregg W StoneUNKNOWN HORIZONS-AMI Trial Investigators
Nov 1, 2007·EuroIntervention : Journal of EuroPCR in Collaboration with the Working Group on Interventional Cardiology of the European Society of Cardiology·Arnoud W J van 't HofJurriën M Ten Berg

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Citations

Sep 4, 2009·Clinical Research in Cardiology : Official Journal of the German Cardiac Society·Ingo EitelHolger Thiele
Mar 17, 2010·Wiener medizinische Wochenschrift·Alois SuessenbacherHannes F Alber
Apr 21, 2009·European Heart Journal·Adam WitkowskiUNKNOWN STEMI 2003 Registry Collaborators
Aug 28, 2012·European Heart Journal·UNKNOWN Task Force on the management of ST-segment elevation acute myocardial infarction of the European Society of Cardiology (ESC)Doron Zahger
Mar 1, 2012·Thrombosis and Haemostasis·Paul C Armstrong, Karlheinz Peter
Nov 6, 2008·Critical Care : the Official Journal of the Critical Care Forum·Uma M Bandarupalli, Gareth Williams
Dec 8, 2011·Circulation Journal : Official Journal of the Japanese Circulation Society·Jung-Sun KimUNKNOWN ECLAT-STEMI Trial investigators
Sep 22, 2010·Drug Design, Development and Therapy·Son V PhamPhuong-Anh T Pham
Sep 10, 2011·Drugs·Marco Valgimigli, Monica Minarelli
Jun 2, 2011·Future Cardiology·Stefan Lischke, David J Schneider
Nov 28, 2012·Heart Views : the Official Journal of the Gulf Heart Association·Mohammed A Balghith
Oct 5, 2010·EuroIntervention : Journal of EuroPCR in Collaboration with the Working Group on Interventional Cardiology of the European Society of Cardiology·Jorik R TimmerUNKNOWN Ongoing Tirofiban In Myocardial Infarction Evaluation (On - Time) 2 study group
Jan 22, 2011·EuroIntervention : Journal of EuroPCR in Collaboration with the Working Group on Interventional Cardiology of the European Society of Cardiology·Cihan Simsek, Eric Boersma
Jul 19, 2011·EuroIntervention : Journal of EuroPCR in Collaboration with the Working Group on Interventional Cardiology of the European Society of Cardiology·Marco Valgimigli
Jul 19, 2011·EuroIntervention : Journal of EuroPCR in Collaboration with the Working Group on Interventional Cardiology of the European Society of Cardiology·Ton HeestermansArnoud W J van 't Hof
Feb 22, 2013·EuroIntervention : Journal of EuroPCR in Collaboration with the Working Group on Interventional Cardiology of the European Society of Cardiology·Giuseppe Biondi-Zoccai, Marco Valgimigli
Feb 9, 2012·EuroIntervention : Journal of EuroPCR in Collaboration with the Working Group on Interventional Cardiology of the European Society of Cardiology·Pascal VranckxUNKNOWN Multicenter Evaluation of Single High-Dose Bolus Tirofiban vs. Abciximab with Sirolimus-Eluting Stent or Bare Metal Stent in
Aug 25, 2012·EuroIntervention : Journal of EuroPCR in Collaboration with the Working Group on Interventional Cardiology of the European Society of Cardiology·Nathalie AssezPatrick Goldstein
Aug 24, 2013·EuroIntervention : Journal of EuroPCR in Collaboration with the Working Group on Interventional Cardiology of the European Society of Cardiology·Miles DalbyUNKNOWN Member of the College of Paramedics
Mar 8, 2013·Future Cardiology·Thomas O BergmeijerJurriën M Ten Berg
Apr 10, 2013·Australian Critical Care : Official Journal of the Confederation of Australian Critical Care Nurses·Samantha J CluneMaria Murphy
Jul 12, 2011·Cardiovascular Drugs and Therapy·Renicus S HermanidesUNKNOWN On-TIME 2 trial investigators
Oct 22, 2011·Clinical Research in Cardiology : Official Journal of the German Cardiac Society·Steffen DeschHolger Thiele
Jul 27, 2010·Netherlands Heart Journal : Monthly Journal of the Netherlands Society of Cardiology and the Netherlands Heart Foundation·W J KikkertJ P S Henriques
Sep 27, 2014·EuroIntervention : Journal of EuroPCR in Collaboration with the Working Group on Interventional Cardiology of the European Society of Cardiology·Bernardo CorteseMarco Valgimigli

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