Prehospital tranexamic acid: what is the current evidence?

Trauma Surgery & Acute Care Open
Lena M Napolitano

Abstract

Many trauma systems are examining whether to implement prehospital tranexamic acid (TXA) protocols since hemorrhage remains the leading cause of potentially preventable early trauma mortality, and early in-hospital administration of TXA within 3 hours of injury is associated with reduced mortality. But robust evidence regarding the efficacy of prehospital administration of the antifibrinolytic drug TXA on trauma outcomes is lacking. This review examines the current evidence available regarding prehospital TXA efficacy in both military and civilian trauma, and updates available evidence regarding in-hospital TXA efficacy in trauma.

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Citations

Aug 9, 2019·Journal of Thrombosis and Haemostasis : JTH·Dominik F DraxlerRobert L Medcalf
Sep 21, 2017·The Journal of Trauma and Acute Care Surgery·Jeffrey T HowardKirby R Gross
Jul 10, 2018·Journal of Trauma Nursing : the Official Journal of the Society of Trauma Nurses·Brody G Eick, Nancy J Denke
Dec 4, 2020·Expert Review of Hematology·Lena M Napolitano
May 17, 2021·Canadian Journal of Anaesthesia = Journal Canadien D'anesthésie·Jean WongAngela Jerath
Dec 16, 2021·European Journal of Trauma and Emergency Surgery : Official Publication of the European Trauma Society·Ayman El-MenyarHassan Al-Thani
Dec 16, 2021·JAMA Surgery·M Margaret KnudsonGeorge C Velmahos

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