Prehypertension and the risk for cardiovascular disease in the Japanese general population: the Jichi Medical School Cohort Study.

Journal of Hypertension
Yukiko IshikawaJichi Medical School Cohort Investigators Group

Abstract

Prehypertension is associated with an increased risk of the development of hypertension and subsequent cardiovascular disease. However, it is unclear whether the increased risk of cardiovascular disease associated with prehypertension varies by duration of follow-up (i.e., the first 5 years vs. second 5 years) or varies between nonelderly and elderly individuals. We enrolled 11,000 community dwelling persons (6739 women and 4261 men, aged 18-90 years) from the Japanese general population, followed them for an average of 10.7 +/- 2.4 years (117,517 person-years) and evaluated the incidence of cardiovascular events (including both stroke and myocardial infarction). In the full cohort, prehypertension was associated with a 45% higher risk of cardiovascular events than normal blood pressure after adjusting for traditional cardiovascular risk factors (hazard ratio = 1.45, P = 0.03). The risk of cardiovascular events with prehypertension during the second 5-year period was elevated in the nonelderly subgroup (<65 years) (hazard ratio = 2.13, P = 0.01), but not in the elderly subgroup (>or=65 years) (hazard ratio = 0.93, P = 0.82) (P = 0.054 for the difference in hazard ratio). The elevated risk with prehypertension during the first 5...Continue Reading

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Citations

Jan 10, 2012·Journal of Cardiovascular Translational Research·Hirofumi Tomiyama, Akira Yamashina
Mar 22, 2013·Hypertension Research : Official Journal of the Japanese Society of Hypertension·Kazuomi Kario
Oct 1, 2011·Kidney International·Yuichiro YanoTsuyoshi Watanabe
May 28, 2011·Pathologie-biologie·M Allal-ElasmiN Kaabachi
Apr 29, 2015·Circulation Journal : Official Journal of the Japanese Circulation Society·Kazuomi KarioUNKNOWN SYMPLICITY HTN-Japan Investigators
Jan 4, 2013·The Journal of Clinical Hypertension·Jason T DavisDaniel T O'Connor
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Feb 18, 2015·Nature Reviews. Cardiology·Brent M Egan, Sean Stevens-Fabry
Dec 17, 2014·Hypertension Research : Official Journal of the Japanese Society of Hypertension·Jeong Bae ParkJi-Guang Wang
May 2, 2012·Hypertension·Hisatomi ArimaUNKNOWN Asia Pacific Cohort Studies Collaboration
Jul 25, 2019·Journal of Hypertension·Minghui HanDongsheng Hu
Apr 30, 2019·Heart Asia·Fabio AngeliPaolo Verdecchia
Sep 19, 2019·The Journal of Clinical Hypertension·Kazuomi KarioJi-Guang Wang
Jan 31, 2017·Journal of Epidemiology·Yukiko IshikawaUNKNOWN Jichi Medical School Cohort Investigators Group
Dec 16, 2020·The Journal of Clinical Hypertension·Kazuomi KarioJi-Guang Wang
Apr 5, 2021·The Journal of Clinical Hypertension·Yanlong RenChangsheng Ma

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