Prehypertension increases the risk of atherosclerosis in drug-naïve Japanese patients with type 2 diabetes mellitus

PloS One
Ippei Kanazawa, Toshitsugu Sugimoto

Abstract

Hypertension is a risk factor of atherosclerotic diseases. However, the importance of prehypertension in Japanese patients with type 2 diabetes mellitus (T2DM) is controversial. The aim of this study was to examine association between prehypertension, hypertension and atherosclerosis in T2DM. We recruited 179 Japanese patients with T2DM, who never took any medication for diabetes, hypertension, dyslipidemia, or atherosclerosis. Intima-media thickness (IMT) of common carotid artery was evaluated by high-resolution B-mode ultrasonography. Multiple regression analysis adjusted for age, duration of diabetes, body mass index, HbA1c, fasting C-peptide, triglyceride, HDL-cholesterol, LDL-cholesterol, and estimated glomerular filtration rate showed that systolic blood pressure (SBP), but not diastolic BP, was significantly and positively associated with maximum IMT (IMT-max), mean IMT, and plaque score (β = 0.28, p<0.001; β = 0.26, p = 0.047; and β = 0.25, p = 0.006, respectively). ROC analysis showed that the cut-off value of SBP to detect atherosclerosis (IMT-max 1.8mm, the mean of IMT-max of this subjects) was 133.5 (p = 0.008), while DBP was not useful to detect it (p = 0.433). Then, participants were categorized as normotension (S...Continue Reading

References

Jan 31, 2003·The New England Journal of Medicine·Peter GaedeOluf Pedersen
Mar 7, 2008·Stroke; a Journal of Cerebral Circulation·Robert J AdamsUNKNOWN American Stroke Association
Jun 10, 2008·The New England Journal of Medicine·Anushka PatelFlorence Travert
Jun 14, 2008·American Journal of Hypertension·Altan OnatGülay Hergenç
Nov 6, 2008·The Journal of Clinical Endocrinology and Metabolism·Ippei KanazawaToshitsugu Sugimoto
Mar 17, 2010·The New England Journal of Medicine·William C CushmanFaramarz Ismail-Beigi
Oct 7, 2010·Journal of Diabetes·Jiao-Rong TanXiao-Ying Li
Mar 4, 2011·The New England Journal of Medicine·Hertzel C GersteinWilliam T Friedewald

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