Prehypertension is Associated With Abnormalities of Cardiac Structure and Function in the Atherosclerosis Risk in Communities Study

American Journal of Hypertension
Angela B S SantosScott D Solomon

Abstract

Prehypertension (blood pressure (BP) of 120-139 mm Hg systolic and/or 80-89 mm Hg diastolic) is highly prevalent and is associated with increased cardiovascular risk. Our goal was to investigate the extent to which prehypertension is associated with end-organ alterations in cardiac structure and function in a large biracial cohort of older men and women. We studied 4,871 participants of the Atherosclerosis Risk in Communities (ARIC) study who attended visit 5 (2011-2013) and underwent two-dimensional echocardiography while free of prevalent coronary heart disease or heart failure. We categorized participants into 3 groups: optimal BP (BP <120 mm Hg and <80 mm Hg) (n = 402), prehypertension (n = 537), and hypertension (n = 3,932). Individuals with prehypertension (75±5 years) had higher left ventricular (LV) mass index and wall thickness, and higher prevalence of abnormal LV geometry than those with optimal BP (74±5 years), but lower than those with frank hypertension (76±5 years). In addition, participants with prehypertension had impairment of diastolic parameters (E/A, E' and E/E'), and had higher prevalence of mild and moderate-severe diastolic dysfunction compared to those with optimal BP, but no differences in systolic par...Continue Reading

References

Jan 17, 2002·The New England Journal of Medicine·R S VasanD Levy
May 16, 2003·JAMA : the Journal of the American Medical Association·Aram V ChobanianUNKNOWN National High Blood Pressure Education Program Coordinating Committee
Jan 30, 2004·Annual Review of Medicine·William H Gaasch, Michael R Zile
Oct 27, 2004·Archives of Internal Medicine·Louise B RussellJeffrey L Carson
Oct 6, 2005·Circulation·Margaret M RedfieldDavid A Kass
Jan 31, 2006·The American Journal of Medicine·Abhijit V KshirsagarRomulo E Colindres
Nov 9, 2006·JAMA : the Journal of the American Medical Association·Francesca BursiVéronique L Roger
Feb 21, 2007·Circulation·Judith HsiaUNKNOWN Women's Health Initiative Investigators
Mar 6, 2007·Journal of the American Society of Echocardiography : Official Publication of the American Society of Echocardiography·Gila PerkItzhak Kronzon
Jan 24, 2009·Stroke; a Journal of Cerebral Circulation·Efstathios ManiosNikolaos Zakopoulos
Jan 2, 2010·American Journal of Hypertension·Vitantonio Di BelloRoberto Pedrinelli
Jun 11, 2010·Hypertension Research : Official Journal of the Japanese Society of Hypertension·Alok K GuptaWilliam D Johnson
Nov 5, 2013·Journal of the American College of Cardiology·Elisabeth Kraigher-KrainerUNKNOWN PARAMOUNT Investigators
Dec 20, 2013·JAMA : the Journal of the American Medical Association·Eric D PetersonPhilip Greenland
Mar 14, 2014·Neurology·Yuli HuangDingli Xu

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Citations

Jan 27, 2017·Hypertension Research : Official Journal of the Japanese Society of Hypertension·Ju Young JungJae-Hon Lee
Aug 12, 2016·Journal of Hypertension·Nils LehmannUNKNOWN Heinz Nixdorf Recall Study Investigators
Mar 5, 2019·Journal of Hypertension·Cesare CuspidiGiuseppe Mancia
Dec 24, 2019·Hypertension·Flávio D Fuchs, Paul K Whelton
Feb 8, 2020·American Journal of Hypertension·Weili DuanZhaoqing Sun
Sep 23, 2018·Journal of Human Hypertension·Cesare CuspidiGiuseppe Mancia
Feb 6, 2020·Current Hypertension Reports·Chike C Nwabuo, Ramachandran S Vasan
Feb 26, 2021·Journal of Cardiovascular Translational Research·Ye-Shi ChenKai Yin
Jun 29, 2021·Frontiers in Cardiovascular Medicine·Floran SahitiStefan Störk
Sep 2, 2021·International Journal of General Medicine·Xiaowen ZuoGuang Zhi

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