Preimplantation genetic testing for aneuploidy (PGT-A): The biology, the technology and the clinical outcomes

The Australian & New Zealand Journal of Obstetrics & Gynaecology
Hayden Anthony Homer

Abstract

Preimplantation genetic testing for aneuploidy (PGT-A) seeks to identify preimplantation embryos with a normal chromosome complement (euploid) during in vitro fertilisation (IVF). By sifting out embryos with abnormal chromosome numbers (aneuploid), PGT-A should theoretically improve pregnancy success. However, earlier versions of PGT-A were ineffective, and in some cases, detrimental, due to biopsy-induced trauma and because the technology at the time could analyse only a fraction of all chromosomes. More recently, the emergence of technologies enabling all chromosomes to be analysed and a switch to less traumatic blastocyst-stage biopsy have seen widespread uptake of PGT-A. Assessing the full impact of blastocyst biopsy PGT-A requires consideration of multiple factors, including embryonic mosaicism, sensitivity of the technological platform used, embryo loss during long-term in vitro culture, embryo cryopreservation and inter-clinic variability in expertise. Significantly, there hasnt yet been an appropriately designed randomised controlled trial (RCT) of blastocyst biopsy PGT-A analysed by intention-to-treat that accounts for all these parameters on a per-cycle basis. The three RCTs reporting benefits studied outcomes on a pe...Continue Reading

Associated Clinical Trials

Apr 23, 2021·Li-Te Lin, Li-Te Lin

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Citations

Feb 19, 2021·Zygote : the Biology of Gametes and Early Embryos·Shun XiongGuo Ning Huang
Feb 18, 2021·The Australian & New Zealand Journal of Obstetrics & Gynaecology·Sarah LensenKarin Hammarberg
May 11, 2021·Human Reproduction Update·Ursula BlythMeenakshi Choudhary
Jun 11, 2021·The Australian & New Zealand Journal of Obstetrics & Gynaecology·Hayden Anthony Homer
Jul 9, 2021·Seminars in Reproductive Medicine·Ariadne L'HevederJara Ben Nagi
Jul 31, 2021·Nature Communications·Ali H BrivanlouNorbert Gleicher
Jul 31, 2021·Nature Communications·Ali H Brivanlou, Norbert Gleicher

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