Preimplantation genetic testing: indications and controversies.

Clinics in Laboratory Medicine
Amber R Cooper, Emily S Jungheim

Abstract

In the last two decades, the use of preimplantation genetic testing has increased dramatically. This testing is used for identifying singlegene disorders, chromosomal abnormalities, mitochondrial disorders, gender selection in non-mendelian disorders with unequal gender distribution, aneuploidy screening, and other preconceptually identified genetic abnormalities in prospective parents. Genetic testing strategies and diagnostic accuracy continues to improve, but not without risks or controversies. In this review the authors discuss the techniques and clinical application of preimplantation genetic diagnosis, and the debate surrounding its associated uncertainty and expanded use.

References

Jul 1, 1992·Proceedings of the National Academy of Sciences of the United States of America·L ZhangN Arnheim
Apr 9, 1981·Nature·S AndersonI G Young
Aug 27, 1998·American Journal of Human Genetics·D R MarchingtonJ Poulton
Jun 28, 2001·JAMA : the Journal of the American Medical Association·Y VerlinskyA Kuliev
Sep 29, 2001·Molecular and Cellular Endocrinology·S RechitskyY Verlinsky
Aug 30, 2002·The New England Journal of Medicine·Tarun JainMark D Hornstein
Dec 31, 2002·JAMA : the Journal of the American Medical Association·Marshalyn Yeargin-AllsoppCatherine Murphy
Jan 23, 2003·Reproductive Biomedicine Online·Susan Crockin
Feb 27, 2004·Molecular Human Reproduction·Dong Gui HuNicole Hussey
Aug 21, 2004·Human Reproduction Update·Anver Kuliev, Yury Verlinsky
Sep 15, 2004·Fertility and Sterility·UNKNOWN Practice Committee of the American Society for Reproductive Medicine
Oct 22, 2004·Nature·Carina Dennis
Feb 11, 2005·The New England Journal of Medicine·Debora Spar
Dec 1, 2005·Seminars in Reproductive Medicine·W G KearnsE Widra
May 16, 2006·Nucleic Acids Research·Cedric Le CaignecJoris R Vermeesch
Jun 16, 2006·Human Reproduction·An MichielsCatherine Staessen
Oct 27, 2006·The Journal of Molecular Diagnostics : JMD·Bassem A Bejjani, Lisa G Shaffer
Mar 3, 2007·Journal of Assisted Reproduction and Genetics·Elpida Fragouli
May 10, 2007·Nature Protocols·Claudia SpitsKaren Sermon
Jul 6, 2007·The New England Journal of Medicine·Sebastiaan MastenbroekFulco van der Veen
Jul 14, 2007·Fertility and Sterility·Susannah BaruchKathy L Hudson
Jan 29, 2008·Human Reproduction·David J Amor, Carolyn Cameron
Apr 4, 2008·Human Reproduction Update·UNKNOWN ESHRE Capri Workshop Group
Jul 22, 2008·Human Reproduction·V GoossensUNKNOWN European Society of Human Reproduction and Embryology PGD Consortium
Jul 31, 2008·Human Reproduction·A L BredenoordG De Wert
Oct 9, 2008·JAMA : the Journal of the American Medical Association·Bridget M Kuehn
Nov 26, 2008·Fertility and Sterility·UNKNOWN Practice Committee of Society for Assisted Reproductive Technology, UNKNOWN Practice Committee of American Society for Reproductive Medicine
Dec 9, 2008·Fertility and Sterility·Anne Drapkin LyerlyEdward Wallach
Dec 17, 2008·Bioethics·Julian Savulescu, Guy Kahane
Dec 23, 2008·Prenatal Diagnosis·Claudia Spits, Karen Sermon

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Citations

Jan 6, 2012·The New England Journal of Medicine·Joann Bodurtha, Jerome F Strauss
Sep 24, 2019·Nigerian Medical Journal : Journal of the Nigeria Medical Association·Eunice I OribamiseOladimeji O Moruf

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