PMID: 8462992Jan 1, 1993Paper

Preimplantation mouse embryos express Mhc class I genes before the first cleavage division

Immunogenetics
M T SprinksN Fernandez

Abstract

We have used oligonucleotide primers complementary for polymorphic regions of the mouse H-2D gene in a highly sensitive polymerase chain reaction (PCR) assay to detect the transcription of maternal and paternal class I mRNAs in gametes and preimplantation embryos. Using congenic strains of mice differing only at the major histocompatibility loci, class I (H-2D) mRNA of both the maternal and paternal haplotypes was demonstrated in embryos from the one-cell zygote to the late blastocyst stage of development but could not be detected in vas deferens or in vitro capacitated sperm or in ovulated secondary oocytes. These data clearly show that both paternally and maternally inherited Major histocompatibility complex (Mhc) class I genes are transcribed from the earliest stages of embryonic development, and suggest that developmental regulation of expression of their protein products is principally at the post-transcriptional level.

References

Oct 1, 1977·The Journal of Experimental Medicine·C G WebbG M Edelman
Jul 1, 1992·Proceedings of the National Academy of Sciences of the United States of America·L JaffeE K Bikoff
Jan 1, 1991·Immunogenetics·S SchwemmleE H Weiss
Jan 1, 1990·Immunogenetics·J KleinS W Hunt
Feb 1, 1988·Biology of Reproduction·C M WarnerM A Ewoldsen
Oct 1, 1986·Proceedings of the National Academy of Sciences of the United States of America·H AllenR Flavell
May 1, 1982·Proceedings of the National Academy of Sciences of the United States of America·A A ReyesR B Wallace
May 1, 1982·Biology of Reproduction·S B GoldbardC M Warner
Jun 10, 1982·The Journal of Experimental Zoology·K M Cozad, C M Warner
Sep 1, 1982·Biology of Reproduction·S B Goldbard, C M Warner
Jan 1, 1993·Journal of Reproductive Immunology·A Reyes-EngelN Fernandez

❮ Previous
Next ❯

Citations

Jan 4, 2001·Molecular Reproduction and Development·A Brunet-SimonV Duranthon
Jan 5, 2002·Molecular Reproduction and Development·Maurizio ZuccottiCarlo Alberto Redi
Apr 1, 1996·Immunology and Cell Biology·A Saberivand, P M Outteridge
Jan 9, 1996·Proceedings of the National Academy of Sciences of the United States of America·A JurisicovaC L Librach
Oct 9, 1998·American Journal of Reproductive Immunology : AJRI·J C CooperG B Dealtry
Jul 1, 1997·European Journal of Immunology·D FiszerM Kurpisz
Jan 2, 1995·American Journal of Medical Genetics·M FiddlerE Pergament
Feb 19, 2011·Journal of Reproductive Immunology·Gérard ChaouatNathalie Lédée
Apr 2, 2010·Journal of Reproductive Immunology·Ayesha ShakhawatNelson Fernández
Feb 2, 2010·Reproductive Biomedicine Online·Valerie ShaiklyNelson Fernández
Jan 23, 1999·Biology of Reproduction·P ArckD Clark
Feb 1, 1996·Immunology and Cell Biology·S HayakawaK Satoh
Nov 1, 1994·Zygote : the Biology of Gametes and Early Embryos·A AoA H Handyside
Nov 18, 2000·Journal of Endocrinological Investigation·M ZuccottiC A Redi

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.