Preischemic induction of TNF-alpha by physical exercise reduces blood-brain barrier dysfunction in stroke

Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism
Miao GuoYuchuan Ding

Abstract

This study explores the neuroprotective action of tumor necrosis factor-alpha (TNF-alpha) induced during physical exercise, which, consequently, reduces matrix metalloproteinase-9 (MMP-9) activity and ameliorates blood-brain barrier (BBB) dysfunction in association with extracellular signal-regulated kinase 1 and 2 (ERK1/2) phosphorylation. Adult male Sprague-Dawley rats were subjected to exercise on a treadmill for 3 weeks. A 2-h middle cerebral artery occlusion and reperfusion was administered to exercised and nonexercised animals to induce stroke. Exercised ischemic rats were subjected to TNF-alpha inhibition and ERK1/2 by TNF-alpha antibody or UO126. Nissl staining of coronal sections revealed the infarct volume. Evans blue extravasation and water content evaluated BBB function. Western blot was performed to analyze protein expression of TNF-alpha, ERK1/2, phosphorylated ERK1/2, the basal laminar protein collagen IV, and MMP-9. The activity of MMP-9 was determined by gelatin zymography. Tumor necrosis factor-alpha expression and ERK1/2 phosphorylation were upregulated during exercise. Infarct volume, brain edema, and Evans blue extravasation all significantly decreased in exercised ischemic rats. Collagen IV production incr...Continue Reading

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Citations

Jan 5, 2011·Translational Stroke Research·Jeffrey M Gidday
Aug 19, 2010·International Journal of Molecular Sciences·Feng ZhangYang Wang
Jan 23, 2010·Neurological Research·Nathan ZwagermanYuchuan Ding
Mar 19, 2014·International Journal of Molecular Sciences·Li ZhangJie Jia
Sep 4, 2009·Neurological Research·Nathan ZwagermanYuchuan Ding
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Apr 15, 2015·Physiology & Behavior·Mohammad Esmaiel AfzalpourHossein Abtahi Eivari
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Apr 5, 2013·Journal of Neuroscience Research·David DornbosYuchuan Ding
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Sep 4, 2016·Journal of Stroke and Cerebrovascular Diseases : the Official Journal of National Stroke Association·Luwen ZhuYunfei Jiang
Feb 6, 2020·Physical Therapy Research·Harutoshi Sakakima
Nov 21, 2017·Sleep Medicine Reviews·Matthew D RockstromJames M Krueger

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Methods Mentioned

BETA
Enzyme-Linked Immunoabsorbent Assay

Software Mentioned

SPSS

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