Prejunctional inhibition of non-adrenergic non-cholinergic transmission in the rat anococcygeus muscle.

European Journal of Pharmacology
C G Li, M J Rand

Abstract

The muscarinic agonist McN-A-343 did not affect the tone or nitroprusside-induced relaxations of the rat anococcygeus, but inhibited non-adrenergic non-cholinergic (NANC) relaxations. Atropine, pirenzepine and gallamine blocked the McN-A-343 inhibition of NANC relaxations. Agonists of alpha 1-(methoxamine) or alpha 2-adrenoceptors (clonidine, rilmenidine) increased tone and reduced NANC relaxations. Carbachol also increased tone but produced a greater reduction of NANC relaxations. The findings suggest that activation of prejunctional muscarinic receptors on NANC terminals inhibits transmitter release, but there is no evidence for prejunctional alpha-adrenoceptors.

Citations

Mar 6, 2002·British Journal of Pharmacology·Juan V Esplugues
May 4, 1999·Clinical and Experimental Pharmacology & Physiology·F JiangM J Rand
Feb 4, 2003·Clinical and Experimental Pharmacology & Physiology·David Story
Feb 1, 1992·Clinical and Experimental Pharmacology & Physiology·M J Rand, C G Li
Jan 1, 1994·Clinical and Experimental Pharmacology & Physiology·A NajbarM J Rand
Aug 1, 1993·British Journal of Pharmacology·G E BoeckxstaensY M Van Maercke
Dec 1, 1989·Clinical and Experimental Pharmacology & Physiology·C G Li, M J Rand
May 31, 2012·Pharmacology & Therapeutics·Frederick J Mitchelson
Sep 25, 2003·British Journal of Pharmacology·Francesc Jimenez-AltayoElisabet Vila
Nov 1, 1993·Archives Internationales De Physiologie, De Biochimie Et De Biophysique·I T Uzbay, R Onur
Oct 1, 1990·British Journal of Pharmacology·A De LucaH K Wong-Dusting

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