Preliminary analysis of proteome alterations in non-aneurysmal, internal mammary artery tissue from patients with abdominal aortic aneurysms

PloS One
Christina Lund KidholmLars Melholt Rasmussen

Abstract

The pathogenesis of abdominal aortic aneurysms (AAA) involves a disturbed balance of breakdown and buildup of arterial proteins. We envision that individuals with AAA carry generalized arterial protein alterations either because of effects of genetically or environmental AAA risk factors or because of compensatory changes due to signaling molecules released from the affected aneurysmal tissue. Protein extraction and quantitative proteome analysis by LC-MS/MS (liquid chromatography-mass spectrometry) was done on individual samples from the internal mammary artery from 11 individuals with AAA and 33 sex- and age-matched controls without AAA. Samples were selected from a biobank of leftover internal mammary arterial tissue gathered at coronary by-pass operations. We identified and quantitated 877 proteins, of which 44 were differentially expressed between the two groups (nominal p-values without correction for multiple testing). Some proteins related to the extracellular matrix displayed altered concentrations in the AAA group, particularly among elastin-related molecules [elastin, microfibrillar-associated protein 4 (MFAP4), lysyl oxidase]. In addition, several histones e.g. (e.g. HIST1H1E, HIST1H2BB) and other vascular cell prot...Continue Reading

References

Mar 1, 1991·Proceedings of the Society for Experimental Biology and Medicine·G C HunterC D Eskelson
Sep 1, 1990·Circulation·S AnidjarJ B Michel
Oct 1, 1994·The Journal of Surgical Research·D J MinionB T Baxter
Nov 18, 1996·Annals of the New York Academy of Sciences·A Ghorpade, B T Baxter
Jul 1, 1997·European Journal of Vascular and Endovascular Surgery : the Official Journal of the European Society for Vascular Surgery·J S LindholtH Fasting
Oct 9, 1998·Arteriosclerosis, Thrombosis, and Vascular Biology·V DavisB T Baxter
Jun 22, 1999·European Journal of Vascular and Endovascular Surgery : the Official Journal of the European Society for Vascular Surgery·J S LindholtH Fasting
Sep 14, 2000·European Journal of Vascular and Endovascular Surgery : the Official Journal of the European Society for Vascular Surgery·J S LindholtL Heickendorff
Dec 9, 2000·European Journal of Vascular and Endovascular Surgery : the Official Journal of the European Society for Vascular Surgery·E PetersenK A Angquist
May 16, 2001·European Journal of Vascular and Endovascular Surgery : the Official Journal of the European Society for Vascular Surgery·J S LindholtE W Henneberg
Oct 13, 2004·Gerontology·Kevin J DalyCharles N McCollum
Nov 27, 2009·Journal of Vascular Surgery·Carl Magnus WahlgrenJesper Swedenborg
Apr 3, 2010·Arteriosclerosis, Thrombosis, and Vascular Biology·Stein Harald JohnsenBjarne Koster Jacobsen
Aug 3, 2010·Interactive Cardiovascular and Thoracic Surgery·Sigitas UrbonaviciusBent Honoré
May 20, 2011·Molecular & Cellular Proteomics : MCP·Athanasios DidangelosManuel Mayr
Aug 27, 2011·Arteriosclerosis, Thrombosis, and Vascular Biology·Jiusong SunGuo-Ping Shi
Sep 20, 2011·Clinical Chemistry·Claudia CangemiLars Melholt Rasmussen
Aug 21, 2012·American Journal of Physiology. Heart and Circulatory Physiology·Ebony Washington RemusW Robert Taylor
Mar 5, 2014·Proteomics. Clinical Applications·Joseph V MoxonJonathan Golledge
Apr 8, 2014·Neurochemical Research·Hans Christian BeckChristian Morsczeck
Jun 4, 2014·Proteomics. Clinical Applications·Roxana Martinez-PinnaJose Luis Martin-Ventura
Jun 18, 2014·Biochimica Et Biophysica Acta·Renjing LiuKathleen A Martin
Jul 1, 2014·Proteomics. Clinical Applications·Roxana Martinez-PinnaJose Luis Martin-Ventura
Jan 31, 2015·Journal of Diabetes and Its Complications·Maria Lyck Hansen, Lars Melholt Rasmussen
May 15, 2015·Atherosclerosis·Bradley J ToghillMatthew J Bown
May 21, 2015·International Journal of Molecular Sciences·Evan J RyerGerard Tromp
Aug 27, 2015·Expert Review of Cardiovascular Therapy·Helena KuivaniemiGerard Tromp
Mar 2, 2016·Atherosclerosis·Anne-Sofie Allermann FaarvangLars Melholt Rasmussen
Dec 10, 2016·Scientific Reports·Elena BurilloJose Luis Martin-Ventura

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Citations

Oct 17, 2019·Biomolecules·José Martínez-GonzálezCristina Rodríguez
Apr 13, 2021·Expert Review of Proteomics·Jianqiang WuYuehong Zheng

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Methods Mentioned

BETA
coronary
acetylation

Software Mentioned

Proteome Discoverer
Mascot

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