PMID: 7539475Jun 1, 1995Paper

Preliminary assessment of a human recombinant antibody fragment to hsp90 in murine invasive candidiasis

The Journal of Infectious Diseases
Ruth C MatthewsJames P Burnie

Abstract

Seroconversion to hsp90 is associated with recovery from systemic candidiasis in humans, and a murine monoclonal antibody to this hsp90 antigen (LKVIRK epitope) was protective in mice. A human recombinant antibody to the same epitope was assessed in acute and chronic models of murine invasive candidiasis. Lethal intravenous challenge with fluconazole-susceptible (strain 4) or fluconazole-resistant (strain 019) Candida albicans, followed 2 h later by a single dose of recombinant antibody, was associated with a statistically significant drop in mortality of > or = 40% (two experiments in BALB/c mice given strain 4; one experiment in CD-1 mice given strain 019) or 23% (BALB/c mice, strain 019). In mice sublethally infected with strain 4, treatment with recombinant antibody was associated with improved renal clearance of infection. Antibody-mediated protection may involve neutralization of the protein-binding properties of circulating candidal hsp90, since LKVIRK strongly bound dexamethasone in vitro.

Citations

Sep 1, 1996·Trends in Microbiology·R Matthews, J Burnie
Sep 24, 2004·FEMS Yeast Research·Walter MaglianiLuciano Polonelli
Mar 26, 2004·Vaccine·Ruth C Matthews, James P Burnie
Jan 23, 1998·Contraception·L ZeitlinR A Cone
Nov 1, 2001·Journal of Immunological Methods·C G HaidarisM A Sullivan
Aug 28, 1998·Research in Immunology·R Matthews, J Burnie
Jul 12, 2002·FEMS Immunology and Medical Microbiology·James BurnieRuth Matthews
Nov 9, 2002·FEMS Immunology and Medical Microbiology·Foroogh NejatollahiJames P Burnie
Dec 4, 2003·The Lancet Infectious Diseases·Philippe EggimannDidier Pittet
Dec 13, 2006·Nature Reviews. Microbiology·Jim E CutlerBruce S Klein
Mar 29, 2000·Scandinavian Journal of Immunology·C SvanholmM E Rottenberg
Aug 31, 2001·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·A Casadevall, L A Pirofski
Mar 23, 2002·The Journal of Antimicrobial Chemotherapy·S M WigfieldJ P Burnie
Jun 25, 2003·Antimicrobial Agents and Chemotherapy·Ruth C MatthewsJames Burnie
Jul 26, 2005·Infection and Immunity·Nicole DenikusUtz Reichard
Oct 30, 2001·Journal of Clinical Microbiology·K Y YuenL Cao
Feb 8, 2003·Journal of Clinical Microbiology·Patrick C Y WooKwok-Yung Yuen
Sep 6, 2008·Microbiology and Molecular Biology Reviews : MMBR·W LaJean Chaffin
Nov 13, 1998·Infectious Diseases in Obstetrics and Gynecology·C O'ConnorB Larsen
Nov 18, 2015·Immunological Investigations·Kausik Datta, Mawieh Hamad
Mar 5, 2004·Expert Opinion on Biological Therapy·James Burnie, Ruth Matthews
Jan 5, 2010·Vaccine·Alice M RibeiroMaria Sueli S Felipe
Aug 11, 2015·Journal of Proteome Research·Paulo S R CoelhoDavid A Stevens
Jan 28, 2006·FEMS Microbiology Reviews·James P BurnieRuth C Matthews
Dec 31, 1996·FEMS Immunology and Medical Microbiology·S HodgettsJ Burnie
Dec 6, 2003·Critical Reviews in Oral Biology and Medicine : an Official Publication of the American Association of Oral Biologists·Florence GoulhenDenis Mayrand
Apr 19, 2005·Medical Mycology·A Brian Mochon, Jim E Cutler
Jun 16, 2004·FEMS Immunology and Medical Microbiology·José L López-RibotJosé P Martínez
Jun 29, 2002·Nature Biotechnology·Carina KrügerLennart Hammarström
Oct 9, 2014·Mycoses·Brad MoriyamaScott R Penzak
Nov 28, 2012·Mycopathologia·Isaque Medeiros SiqueiraAnamélia Lorenzetti Bocca

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