Preliminary bioavailability study on protacine: a new, non-steroidal anti-inflammatory agent

Current Medical Research and Opinion
A A Bignamini, P L Casula


Time versus concentration curves of unchanged protacine were measured in the blood of 5 healthy volunteers by high pressure liquid chromatography after a single oral dose of 4 capsules (600 mg). These curves showed a maximum at 8 hours after administration, with an absorption half-life of 3.4 hours, and were interpreted according to the two-compartment open model with invasion. The elimination half-life was found to be 10 hours. This may allow a maintenance treatment, where necessary, with 1 capsule (150 mg) of protacine twice daily and strongly suggests that, apart from acute cases, protacine would be particularly well suited for long-term treatment.


Jun 1, 1978·Pharmacological Research Communications·R R Vidal y PlanaA L Rovati
Jan 1, 1979·Current Medical Research and Opinion·V PipitoneA A Bignamini

Related Concepts

Microbial Anatomical Capsule Structure
Anti-Inflammatory Agents
Nonsteroidal Anti-inflammatory Drug [EPC]
Anti-Inflammatory Agents, Non-Steroidal
High Pressure Liquid Chromatography Procedure
Anatomical Compartments
Hydrogen-Ion Concentration
Structure of Organ Capsule

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