PMID: 8953662Nov 1, 1996Paper

Preliminary confirmation of the proposed link between reward-dependence traits and norepinephrine

Psychiatry Research
M J GarveyN Blum

Abstract

The tridimensional theory of personality posits that traits belonging to a personality spectrum called 'reward dependence' are determined in part by the neurotransmitter norepinephrine (NE). We hypothesized that urinary levels of the NE metabolite 3-methoxy-4-hydroxyphenylglycol (MHPG) would be significantly correlated to the reward dependence score on the Tridimensional Personality Questionnaire (TPQ). Twenty-seven never psychiatrically ill subjects collected urine for MHPG measurements and completed the TPQ. There was a significant correlation between the reward dependence score and the level of MHPG. MHPG levels was not associated with the other two personality dimensions, novelty seeking and harm avoidance. This preliminary study supports the hypothesis that reward-dependence traits are in part determined by NE.

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Citations

May 20, 2000·Psychoneuroendocrinology·G GerraF Brambilla
Nov 5, 1998·Psychoneuroendocrinology·M Hansenne, M Ansseau
Jan 9, 2001·Journal of Substance Abuse·G GerraF Brambilla
Sep 5, 2001·European Neuropsychopharmacology : the Journal of the European College of Neuropsychopharmacology·A J Bond
Dec 29, 2011·Depression Research and Treatment·Jaap G Goekoop, Remco F P De Winter
Apr 4, 2014·TheScientificWorldJournal·Rupert ConradAndrea Karpawitz-Godt
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Aug 9, 2005·Journal of Personality Assessment·Michel HansenneC Robert Cloninger
Jan 27, 2005·Journal of Psychopharmacology·Wai S Tse, Alyson J Bond
Apr 1, 2012·Therapeutic Advances in Psychopharmacology·Jaap G GoekoopVictor M Wiegant
Sep 5, 2002·American Journal of Medical Genetics·Shih-Jen TsaiChen-Jee Hong
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