Preliminary Data on COVID-19 in Patients with Hemoglobinopathies: A Multicentre ICET-A Study

Mediterranean Journal of Hematology and Infectious Diseases
Vincenzo de SanctisSalvatore Di Maio

Abstract

This study aims to investigate, retrospectively, the epidemiological and clinical characteristics, laboratory results, radiologic findings, and outcomes of COVID-19 in patients with transfusion-dependent β thalassemia major (TM), β-thalassemia intermedia (TI) and sickle cell disease (SCD). A total of 17 Centers, from 10 countries, following 9,499 patients with hemoglobinopathies, participated in the survey. Clinical, laboratory, and radiologic findings and outcomes of patients with COVID-19 were collected from medical records and summarized. A total of 13 patients, 7 with TM, 3 with TI, and 3 with SCD, with confirmed COVID-19, were identified in 6 Centers from different countries. The overall mean age of patients was 33.7±12.3 years (range:13-66); 9/13 (69.2%) patients were females. Six patients had pneumonia, and 4 needed oxygen therapy. Increased C-reactive protein (6/10), high serum lactate dehydrogenase (LDH; 6/10), and erythrocyte sedimentation rate (ESR; 6/10) were the most common laboratory findings. 6/10 patients had an exacerbation of anemia (2 with SCD). In the majority of patients, the course of COVID-19 was moderate (6/10) and severe in 3/10 patients. A 30-year-old female with TM, developed a critical SARS-CoV-2 inf...Continue Reading

Citations

Sep 24, 2020·British Journal of Haematology·Dina ShehaAliaa Sheha
Dec 9, 2020·Hematology, Transfusion and Cell Therapy·Thiago de Souza VilelaSandra Regina Loggetto
Mar 21, 2021·International Journal of Infectious Diseases : IJID : Official Publication of the International Society for Infectious Diseases·S AlkindiA V Pathare
Apr 30, 2021·American Journal of Hematology·Rayan Bou-FakhredinAli T Taher
Jun 2, 2021·Pediatric Blood & Cancer·Babak SayadZohreh Rahimi
Jul 5, 2021·Transfusion clinique et biologique : journal de la Société française de transfusion sanguine·Estelle Jean-MignardIsabelle Thuret
Dec 5, 2020·Journal of Pediatric Hematology/oncology·Yesim Oymak, Tuba H Karapinar

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Methods Mentioned

BETA
X-ray
ESR

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