Preliminary evaluation of an aqueous wax emulsion for controlled-release coating

Pharmaceutical Development and Technology
P S WaliaR Turton

Abstract

The purpose of this work was to evaluate the use of an aqueous carnauba wax emulsion (Primafresh HS, Johnson Wax) in a spray-coating process. This involved assessing the effectiveness of the wax in sustaining the release of the drug, theophylline. Second, the process by which the drug was released from the wax-coated pellets was modeled. Finally, a method to determine the optimum blend of pellets with different wax thicknesses, in order to yield a zero-order release profile of the drug, was addressed. Nonpareil pellets were loaded with theophylline using a novel powder coating technique. These drug-loaded pellets were then coated with different levels of carnauba wax in a 6-in. diameter Plexiglas fluid bed with a 3.5-in. diameter Wurster partition. Drug release was measured using a spin-filter dissolution device. The study resulted in continuous carnauba wax coatings which showed sustained drug release profile characteristics typical of a barrier-type, diffusion-controlled system. The effect of varying wax thickness on the release profiles was investigated. It was observed that very high wax loadings would be required to achieve long sustained-release times. The diffusion model, developed to predict the release of the drug, sho...Continue Reading

References

Mar 1, 1978·Journal of Pharmaceutical Sciences·H G SchroederP P DeLuca
Nov 1, 1990·Pharmaceutical Research·M J JozwiakowskiR M Franz
Apr 1, 1995·Journal of Pharmaceutical Sciences·M Otsuka, Y Matsuda
Apr 1, 1996·Pharmaceutical Development and Technology·J P Kennedy, P J Niebergall

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Citations

Oct 6, 2007·AAPS PharmSciTech·Reena SinghAmit Chivate
Sep 19, 2002·Chemical & Pharmaceutical Bulletin·Norihito ShimonoYasuhiko Nakamura

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