Preliminary evaluation of military, commercial and novel skin decontamination products against a chemical warfare agent simulant (methyl salicylate)

Cutaneous and Ocular Toxicology
Hazem MatarRobert P Chilcott

Abstract

Rapid decontamination is vital to alleviate adverse health effects following dermal exposure to hazardous materials. There is an abundance of materials and products which can be utilised to remove hazardous materials from the skin. In this study, a total of 15 products were evaluated, 10 of which were commercial or military products and five were novel (molecular imprinted) polymers. The efficacies of these products were evaluated against a 10 µl droplet of (14)C-methyl salicylate applied to the surface of porcine skin mounted on static diffusion cells. The current UK military decontaminant (Fuller's earth) performed well, retaining 83% of the dose over 24 h and served as a benchmark to compare with the other test products. The five most effective test products were Fuller's earth (the current UK military decontaminant), Fast-Act® and three novel polymers [based on itaconic acid, 2-trifluoromethylacrylic acid and N,N-methylenebis(acrylamide)]. Five products (medical moist-free wipes, 5% FloraFree™ solution, normal baby wipes, baby wipes for sensitive skin and Diphotérine™) enhanced the dermal absorption of (14)C-methyl salicylate. Further work is required to establish the performance of the most effective products identified in...Continue Reading

References

Mar 1, 1975·The Journal of Investigative Dermatology·T J Franz
Nov 1, 1987·Toxicology·S FairhurstD W Swanston
Mar 15, 1982·Toxicology and Applied Pharmacology·R L BronaughE R Congdon
Aug 1, 1996·Annals of Emergency Medicine·T OkumuraS Hinohara
Apr 5, 2001·Journal of Applied Toxicology : JAT·J E RiviereN A Monteiro-Riviere
Aug 2, 2001·Journal of Applied Toxicology : JAT·R P ChilcottP Rice
Aug 24, 2001·The Journal of Pharmacy and Pharmacology·G M El MaghrabyB W Barry
May 15, 2002·Skin Research and Technology : Official Journal of International Society for Bioengineering and the Skin (ISBS) [and] International Society for Digital Imaging of Skin (ISDIS) [and] International Society for Skin Imaging (ISSI)·Hongbo ZhaiHoward I Maibach
Mar 30, 2004·Toxicology in Vitro : an International Journal Published in Association with BIBRA·D J DaviesJ R Heylings
May 12, 2004·Regulatory Toxicology and Pharmacology : RTP·J J M van de SandtF M Williams
Jun 19, 2004·Critical Reviews in Therapeutic Drug Carrier Systems·Carryn H PurdonHoward I Maibach
Jul 15, 2006·Pharmaceutical Research·Christophe HerkenneRichard H Guy
Jul 29, 2006·Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association·Richard P Moody, Howard I Maibach
May 15, 2007·Journal of Toxicology and Environmental Health. Part a·Richard P MoodyIh Chu
Jun 15, 2007·Journal of Occupational and Environmental Hygiene·Pengfei GaoRonald Shaffer
Nov 18, 2008·Toxicology in Vitro : an International Journal Published in Association with BIBRA·Ana M Barbero, H Frederick Frasch
Apr 30, 2009·Journal of Controlled Release : Official Journal of the Controlled Release Society·Mickaël MélotGerwin J Puppels
Aug 1, 1986·International Journal of Cosmetic Science·R C ScottP H Dugard
Jan 15, 2010·Academic Emergency Medicine : Official Journal of the Society for Academic Emergency Medicine·Robert J Feldman
Jun 1, 1997·Toxicology in Vitro : an International Journal Published in Association with BIBRA·R P Moody, B Nadeau
Oct 11, 2011·ACS Applied Materials & Interfaces·W Bruce SalterJoseph D Wander
May 15, 2012·International Journal of Pharmaceutics·Wing Man LauCharles M Heard
Aug 29, 2012·Toxicology in Vitro : an International Journal Published in Association with BIBRA·P RollandS Briançon
Apr 2, 2014·Environment International·Robert P Chilcott

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Citations

Oct 11, 2017·Journal of Applied Toxicology : JAT·Thomas JamesRaquel Duarte-Davidson
Mar 25, 2021·Cutaneous and Ocular Toxicology·Lina ThorsAnders Bucht
Apr 4, 2021·International Journal of Environmental Research and Public Health·Samuel CollinsRichard Amlôt
May 30, 2021·Chemico-biological Interactions·Greta Camilla MagnanoFrancesca Larese Filon

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