Preliminary evaluation of pharmacological properties of some xanthone derivatives

Bioorganic & Medicinal Chemistry
Henryk MaronaEdward Szneler

Abstract

A series of xanthone derivatives were synthesized and examined for electrocardiographic, antiarrhythmic, hypotensive and anticonvulsant activities as well as for alpha(1)- and beta(1)-adrenergic binding affinities. Among the investigated compounds, some of them exhibited significant antiarrhythmic and/or hypotensive activity. The data obtained via receptor binding assay are in agreement with pharmacological results and could explain antiarrhythmic and/or hypotensive activity of the newly synthesized structures.

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Jan 10, 2009·Bioorganic & Medicinal Chemistry·Henryk MaronaEdward Szneler

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Citations

Feb 5, 2013·Bioorganic & Medicinal Chemistry·Natalia SzkaradekHenryk Marona
Apr 29, 2014·Mutation Research. Genetic Toxicology and Environmental Mutagenesis·Karolina SłoczyńskaHenryk Marona
Jan 7, 2016·European Journal of Medicinal Chemistry·Riham F George, Dalia O Saleh
Jul 24, 2012·European Journal of Medicinal Chemistry·Carla FernandesMadalena M Pinto
Mar 31, 2016·The Journal of Antibiotics·Karolina KlesiewiczNatalia Szkaradek
Apr 26, 2016·European Journal of Medicinal Chemistry· Shagufta, Irshad Ahmad
May 23, 2012·Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association·Kok Meng ChanSalmaan Hussain Inayat-Hussain
May 31, 2014·European Journal of Pharmacology·Anna RapaczHenryk Marona
Jan 10, 2009·Bioorganic & Medicinal Chemistry·Henryk MaronaEdward Szneler
Mar 31, 2018·Journal of Asian Natural Products Research·Bei-Dou ZhouDong-Bao Hu
Aug 21, 2016·Chemical Biology & Drug Design·Anna M WaszkielewiczHenryk Marona
Mar 1, 2019·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Carla FernandesMadalena M M Pinto

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