Preliminary evaluation of serial (18) FDG-PET/CT to assess response to toceranib phosphate therapy in canine cancer

Veterinary Radiology & Ultrasound : the Official Journal of the American College of Veterinary Radiology and the International Veterinary Radiology Association
Amy K LeBlancFederica Morandi

Abstract

Palladia(TM) (toceranib phosphate-Pfizer Animal Health) is a novel orally administered receptor tyrosine kinase inhibitor (TKI) approved for treatment of canine mast cell tumors. Receptor tyrosine kinase dysregulation leads to tumor growth, progression, and metastasis. Toceranib's targets include vascular endothelial growth factor receptor (VEGFR-2/Flk-1/KDR), platelet-derived growth factor receptor, and kit. Positron Emission Tomography/Computed Tomography (PET/CT) is used commonly to diagnose, prognosticate, and monitor response to antineoplastic therapy in human patients. In this study, serial PET/CT imaging with (18) F-fluorodeoxyglucose ((18) FDG) was used to assess response to toceranib therapy in dogs with measurable solid malignancies. Six tumor-bearing dogs underwent tumor assessment using both standard RECIST criteria and PET/CT prior to and at a median of 5 weeks postinitiation of toceranib treatment. Toceranib was prescribed initially at a target dose 3.25 mg/kg PO q48 h, with subsequent modifications based on observed toxicity. Treatment was continued in patients achieving stable disease with acceptable drug tolerance. One dog was maintained on drug despite dose modification due to toxicity; measurable clinical and...Continue Reading

References

Apr 21, 1999·Experimental Hematology·C A LondonE N Geissler
Dec 15, 2000·Oncogene·S M Jhiang
May 10, 2001·Journal of the American Veterinary Medical Association·A LangenbachK U Sorenmo
Dec 21, 2002·American Journal of Veterinary Research·Sue DowningCheryl A London
May 3, 2003·Journal of the American Veterinary Medical Association·Laurel E Williams, Rebecca A Packer
Apr 14, 2006·Neoplasia : an International Journal for Oncology Research·Joshua D WebsterMatti Kiupel
May 2, 2007·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Robert S BenjaminChuslip Charnsangavej
Apr 18, 2008·Anti-cancer Drugs·Sarah-Jane DawsonDanny Rischin
Apr 19, 2008·Veterinary Radiology & Ultrasound : the Official Journal of the American College of Veterinary Radiology and the International Veterinary Radiology Association·Amy K LeBancGregory B Daniel
Jun 17, 2008·The Oncologist·Annick D Van den Abbeele
Feb 27, 2009·Cancer Biotherapy & Radiopharmaceuticals·Laetitia VercellinoJean-Luc Moretti
Apr 30, 2009·Veterinary Radiology & Ultrasound : the Official Journal of the American College of Veterinary Radiology and the International Veterinary Radiology Association·Amy K LeBlancGregory B Daniel
Jun 24, 2009·Journal of Nuclear Medicine : Official Publication, Society of Nuclear Medicine·Richard L WahlMartin A Lodge
Aug 25, 2009·Veterinary Radiology & Ultrasound : the Official Journal of the American College of Veterinary Radiology and the International Veterinary Radiology Association·Amy K LeBlancGregory B Daniel
Aug 27, 2009·Cancer Research and Treatment : Official Journal of Korean Cancer Association·So Young YoonHong M Lee
Sep 8, 2009·Topics in Companion Animal Medicine·Cheryl A London
Jan 19, 2010·Journal of Nuclear Medicine : Official Publication, Society of Nuclear Medicine·Cristina LoisDavid W Townsend
Feb 5, 2010·Anti-cancer Drugs·Ovidio Fernández CalvoLuis Miguel Antón Aparicio
Jul 27, 2010·Journal of Computer Assisted Tomography·Alampady Krishna Prasad ShanbhogueSrinivasa R Prasad
Mar 11, 2011·Veterinary Radiology & Ultrasound : the Official Journal of the American College of Veterinary Radiology and the International Veterinary Radiology Association·Anders E HansenAnnemarie T Kristensen
Jul 1, 2009·Therapeutic Advances in Medical Oncology·D K Wilkins, P D Nathan
Jan 13, 2012·Veterinary and Comparative Oncology·C LondonS Gillings

❮ Previous
Next ❯

Citations

Jan 7, 2014·The Journal of Veterinary Medical Science·Jisun KimJihye Choi
Oct 26, 2012·Veterinary Radiology & Ultrasound : the Official Journal of the American College of Veterinary Radiology and the International Veterinary Radiology Association·Elizabeth A BallegeerChelsea M Kunst
Apr 14, 2016·The Veterinary Clinics of North America. Small Animal Practice·Elissa K Randall
Nov 14, 2013·Veterinary Radiology & Ultrasound : the Official Journal of the American College of Veterinary Radiology and the International Veterinary Radiology Association·John H RossmeislShawna Klahn
Dec 21, 2013·Veterinary Radiology & Ultrasound : the Official Journal of the American College of Veterinary Radiology and the International Veterinary Radiology Association·Tarja S JokinenLiisa Metsähonkala
Jan 19, 2016·Veterinary Radiology & Ultrasound : the Official Journal of the American College of Veterinary Radiology and the International Veterinary Radiology Association·Yang FengWilliam H Nailon
Feb 28, 2013·Veterinary Radiology & Ultrasound : the Official Journal of the American College of Veterinary Radiology and the International Veterinary Radiology Association·Hiroto YoshikawaSusan M Larue
Mar 3, 2020·Frontiers in Oncology·David M VailRobert Jeraj

❮ Previous
Next ❯

Related Concepts

Related Feeds

Cell Signaling by Tyrosine Kinases

Receptor tyrosine kinases (RTKs) are the high-affinity cell surface receptors for many polypeptide growth factors, cytokines, and hormones. RTKs have been shown not only to be key regulators of normal cellular processes but also to have a critical role in the development and progression of many types of cancer. Discover the latest research on cell signaling and RTK here.

Cancer Imaging

Imaging techniques, including CT and MR, have become essential to tumor detection, diagnosis, and monitoring. Here is the latest research on cancer imaging.

Cancer Metabolism

In order for cancer cells to maintain rapid, uncontrolled cell proliferation, they must acquire a source of energy. Cancer cells acquire metabolic energy from their surrounding environment and utilize the host cell nutrients to do so. Here is the latest research on cancer metabolism.

Related Papers

Veterinary Radiology & Ultrasound : the Official Journal of the American College of Veterinary Radiology and the International Veterinary Radiology Association
Nicole E MartinezThomas E Johnson
Veterinary Radiology & Ultrasound : the Official Journal of the American College of Veterinary Radiology and the International Veterinary Radiology Association
Hiroto YoshikawaSusan M Larue
Veterinary Radiology & Ultrasound : the Official Journal of the American College of Veterinary Radiology and the International Veterinary Radiology Association
Marcy J SouzaGregory B Daniel
© 2022 Meta ULC. All rights reserved