Preliminary evaluation of the positively and negatively charge effects of tetra-substituted porphyrins on photoinactivation of rapidly growing mycobacteria

Tuberculosis
Kevim Bordignon GuterresBernardo Almeida Iglesias

Abstract

This manuscript reports, at the first time, the photoinactivation evaluation of tetra-cationic and anionic porphyrins as photosensitizers (PS) for the photodynamic inactivation (PDI) of rapidly growing mycobacteria strains. Two different charged porphyrin groups were obtained commercially. PDI experiments in the strains Mycobacterium massiliense e Mycobacterium fortuitum conducted with adequate concentration (without aggregation) of photosensitizer under white light at a fluence rate of 50 mW/cm2 over 90 min showed that the most effective PS caused a 100 times reduction in the concentration of viable mycobacteria. The present results show that porphyrin with positively charge are more efficient PS than anionic porphyrin (negatively charged) against M. massiliense e M. fortuitum. It is also clear that the effectiveness of the molecule as PS for PDI studies with mycobacteria is strongly related with the porphyrin peripheral charge, and consequently their solubility in physiological media. Cationic PSs might be promising anti-mycobacteria PDI agents with potential applications in medical clinical cases and bioremediation.

Citations

Sep 28, 2020·Biometals : an International Journal on the Role of Metal Ions in Biology, Biochemistry, and Medicine·Kevim Bordignon GuterresBernardo Almeida Iglesias
Jun 3, 2021·Biomedicines·Ece Polat, Kyungsu Kang
May 18, 2021·Applied Microbiology and Biotechnology·Margarita ShleevaArseny Kaprelyants
Jul 29, 2021·Photodiagnosis and Photodynamic Therapy·Dariane Clerici JornadaBernardo Almeida Iglesias
Aug 19, 2020·Microbial Pathogenesis·Grazielle Guidolin RossiMarli Matiko Anraku de Campos

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