Preliminary evidence for gender effects of levetiracetam monotherapy duration on bone health of patients with epilepsy

Epilepsy & Behavior : E&B
Artemios K ArtemiadisNikolaos Triantafyllou

Abstract

Enzyme-inducing antiepileptic drugs AEDs have adverse effects on bone mineral density (BMD), whereas studies on levetiracetam (LEV), a nonenzyme-inducing agent, have showed conflicting results. The aim of this study was to further elucidate the role of LEV in bone health. A sample of forty-six patients with epilepsy (mean age: 35.7 years, range: 20.2-64.2 years, 39.1% males) on LEV monotherapy for at least one year (range: 1.5-14.5 years, median 5.5 years) underwent femoral neck (FN) and lumbar spine (LS) BMD measurements. The T- and Z-scores were calculated. Results showed that 15.2% of the patients were identified with osteopenia and none with osteoporosis. Pearson's correlations revealed a negative but not significant association of LEV duration with bone-related measurements (range of rhos: from -0.004 to -0.23), except for LS T-scores. In terms of FN BMD measurements, Z-scores, and T-scores, longer LEV therapy duration had adverse but not significant effects on bone health after adjusting for age and gender. With regard to LS BMD measurements, Z-scores, and T-scores, men taking LEV for at least 5.5 years had better, although not significant, bone health compared with men with shorter LEV exposure, after adjusting for age. ...Continue Reading

References

Aug 1, 1994·Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research·J A KanisN Khaltaev
Oct 13, 2005·Acta Neurologica Scandinavica·P Vestergaard
May 1, 2012·Seizure : the Journal of the British Epilepsy Association·Simona Alexandra BeniczkyNoémi Becser Andersen
Aug 8, 2012·Therapeutic Advances in Musculoskeletal Disease·Christian Meier, Marius E Kraenzlin
Sep 18, 2012·Endocrine Practice : Official Journal of the American College of Endocrinology and the American Association of Clinical Endocrinologists·Richard LeeCathleen Colón-Emeric

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Citations

Sep 1, 2017·Current Opinion in Endocrinology, Diabetes, and Obesity·Philip M Dussault, Antonio A Lazzari

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