Preliminary evidence that azidothymidine does not affect hepatitis B virus replication in acquired immunodeficiency syndrome (AIDS) patients

Journal of Medical Virology
F A FarrayeJ B Zeldis

Abstract

The effect of azidothymidine (AZT) on hepatitis B virus (HBV) replication was determined in three patients with the acquired immunodeficiency syndrome (AIDS). Serum viral DNA was present, and its concentration either remained the same or increased in two patients. Since AIDS patients may be infected with a variety of viral agents in addition to the human immunodeficiency virus (HIV), the effects of the antiviral agents and biological modifiers on other common viral infections should also be determined in developing new approaches to HIV infection. Our results give preliminary evidence that AZT does not affect HBV viral replication in vivo.

Citations

Aug 1, 1992·Journal of Medical Virology·A P CatterallI M Murray-Lyon
Aug 1, 1992·Antiviral Research·L BerkR A Heijtink
Sep 1, 1990·Baillière's Clinical Gastroenterology·J L BrownH C Thomas
Jan 1, 1994·Journal of Viral Hepatitis·A S Lok
Jan 1, 1991·Journal of Gastroenterology and Hepatology·S Locarnini
Dec 21, 2005·Journal of Hepatology·S Locarnini, William S Mason
Mar 1, 1993·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·H L JanssenS W Schalm

Related Concepts

Acquired Immunodeficiency Syndrome
DNA, Viral
Dose-Response Relationship, Drug
Dane Particle
Virus Replication
Retrovir
HIV-1

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