Preliminary evidence that VEGF genetic variability confers susceptibility to frontotemporal lobar degeneration

Rejuvenation Research
Barbara BorroniRoberto Del Bo

Abstract

Frontotemporal lobar degeneration (FTLD) recognizes a strong genetic background, with 30-50% of cases with a positive family history. Despite several efforts to identify monogenic causes of the disease, no clear-cut genetic risk factors for sporadic FTLD are yet known. Recently, increasing evidence points to a pivotal role of vascular endothelial growth factor (VEGF) in the neurodegenerative process, suggesting functions not confined to its originally described vascular effects. The aim of this study was to investigate the role of VEGF as a genetic determinant to FTLD susceptibility. We evaluated a cohort of 274 unrelated Italian patients, including 161 subjects with frontotemporal dementia (FTD), 56 with corticobasal degeneration syndrome, and 57 with progressive supranuclear palsy. Genotype and allele frequencies of four well-known polymorphisms located within the VEGF promoter (-2578C/A, -1190G/A, -1154G/A, and -634G/C) were calculated in patients and in 216 age-matched healthy subjects. Genetic analysis revealed the presence of several significant changes in terms of allele, genotype, and haplotype frequency distributions between patients and controls. Marked differences were observed when the FTD patient subgroup was compa...Continue Reading

References

Jul 1, 1997·Dementia and Geriatric Cognitive Disorders·L GustafsonG Fex
Jun 24, 1998·Proceedings of the National Academy of Sciences of the United States of America·M G SpillantiniB Ghetti
Oct 4, 2000·JAMA : the Journal of the American Medical Association·B A HoslerR H Brown
Nov 16, 2001·Archives of Neurology·G M McKhannUNKNOWN Work Group on Frontotemporal Dementia and Pick's Disease
Feb 2, 2002·The British Journal of Psychiatry : the Journal of Mental Science·Julie S SnowdenDavid M A Mann
Apr 24, 2002·Seminars in Cell & Developmental Biology·Peter Carmeliet, Erik Storkebaum
Jul 2, 2003·Annals of Neurology·Andrew KerteszDavid G Munoz
May 18, 2004·Experimental Neurology·Jeffrey M Rosenstein, Janette M Krum
May 1, 1994·Physics in Medicine and Biology·H H BarrettB M Tsui
Feb 26, 2005·Annals of Neurology·Roberto Del BoGiacomo P Comi
Jul 26, 2005·Nature Genetics·Gaia SkibinskiJohn Collinge
Sep 15, 2005·Archives of Neurology·Barbara BorroniMaria Grazia Spillantini
Nov 30, 2005·Annals of Neurology·Xiaohong LiJames A Mastrianni
Jan 20, 2006·Journal of Neurology, Neurosurgery, and Psychiatry·R SrinivasanD M A Mann
Feb 24, 2006·Brain : a Journal of Neurology·Caroline VanceChristopher E Shaw
Feb 24, 2006·Brain : a Journal of Neurology·Julie van der ZeeBart Dermaut
Sep 14, 2006·Annals of Neurology·Jonathan D RohrerMartin N Rossor
Nov 16, 2006·Rejuvenation Research·Martina ChiappelliFederico Licastro
Nov 23, 2006·Neurobiology of Aging·Roberto Del BoGiacomo Pietro Comi
Mar 14, 2007·Archives of Neurology·Jennifer MurphyCatherine Lomen-Hoerth

❮ Previous
Next ❯

Citations

Aug 14, 2009·European Journal of Neurology : the Official Journal of the European Federation of Neurological Societies·L BenussiG Binetti
Mar 4, 2011·Annals of Indian Academy of Neurology·P M AswathyP S Mathuranath
Oct 21, 2009·Neuromolecular Medicine·Sara LandgrenHenrik Zetterberg
Aug 31, 2011·Journal of Aging Research·Ana-Maria EnciuBogdan O Popescu
Oct 14, 2009·Neuropathology and Applied Neurobiology·S M Pickering-Brown
Feb 12, 2011·Neuro-degenerative Diseases·B BorroniA Padovani
Apr 13, 2017·Human Brain Mapping·Hikaru TakeuchiRyuta Kawashima
Nov 2, 2021·Frontiers in Molecular Neuroscience·Virginie BotteroJudith A Potashkin
Dec 8, 2021·Alzheimer's & Dementia : the Journal of the Alzheimer's Association·Alberto BenussiBarbara Borroni

❮ Previous
Next ❯

Related Concepts

Related Feeds

Arterial-Venous in Development & Disease

Arterial-venous development may play a crucial role in cardiovascular diseases. Here is the latest research.

© 2022 Meta ULC. All rights reserved