Preliminary experience with precipitating hydrophobic injectable liquid in brain arteriovenous malformations

Diagnostic and Interventional Radiology : Official Journal of the Turkish Society of Radiology
Naci KoçerMehmet Yaşar Kaynar

Abstract

Advancement in microcatheter design and emergence of new embolic agents offer better results in endovascular treatment of brain arteriovenous malformations (AVMs). Precipitating hydrophobic injectable liquid (PHIL) (Microvention) is a newly introduced dimethyl sulfoxide-based embolic agent for endovascular use. Herein, we present three patients who underwent endovascular treatment of brain AVMs with PHIL, followed by surgical resection. Endovascular features and same-day surgical handling of the new embolic agent PHIL are presented along with histopathologic changes in the acute stage in brain AVMs are presented, and its major differences from Onyx. In our series, PHIL had moderate inflammatory reaction in the acute stage without any associated angionecrosis that is different than Onyx which cause mild inflammatory reaction with angionecrosis. Smallest vessel containing PHIL was 2.9 μm compared to 5 μm with Onyx, which suggests better penetration.

Citations

Mar 1, 2016·Journal of Controlled Release : Official Journal of the Controlled Release Society·Azadeh PoursaidHamidreza Ghandehari
Jun 15, 2016·Interventional Neuroradiology : Journal of Peritherapeutic Neuroradiology, Surgical Procedures and Related Neurosciences·Matthijs In 't Veld, Peter Wa Willems
Jan 24, 2018·Interventional Neuroradiology : Journal of Peritherapeutic Neuroradiology, Surgical Procedures and Related Neurosciences·Robert JuszkatJarosław Kocięcki
Aug 11, 2018·AJNR. American Journal of Neuroradiology·D F VollherbstM A Möhlenbruch
Sep 19, 2018·Interventional Neuroradiology : Journal of Peritherapeutic Neuroradiology, Surgical Procedures and Related Neurosciences·Stanimir S SirakovRadoslav Raychev
Jun 7, 2019·Advanced Materials·Jingjie HuRahmi Oklu
Mar 21, 2018·Journal of Neurointerventional Surgery·Dominik F VollherbstMarkus A Möhlenbruch
Jul 10, 2017·Journal of Neurointerventional Surgery·Dominik F VollherbstMarkus A Möhlenbruch
Aug 20, 2020·Journal of Materials Chemistry. B, Materials for Biology and Medicine·Jasmine LordAndrew L Lewis
Jul 6, 2018·Interventional Neuroradiology : Journal of Peritherapeutic Neuroradiology, Surgical Procedures and Related Neurosciences·Dominik F VollherbstMarkus A Möhlenbruch
May 22, 2018·Interventional Neuroradiology : Journal of Peritherapeutic Neuroradiology, Surgical Procedures and Related Neurosciences·J R MasonG Benndorf
Mar 7, 2021·Journal of Clinical Medicine·Pierleone LucatelliCarlo Catalano

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