Preliminary findings of cerebral responses on transcutaneous vagal nerve stimulation on experimental heat pain

Brain Imaging and Behavior
Taras I UsichenkoMartin Lotze

Abstract

Transcutaneous vagal nerve stimulation (TVNS) is a promising complementary method of pain relief. However, the neural networks associated with its analgesic effects are still to be elucidated. Therefore, we conducted two functional magnetic resonance imaging (fMRI) sessions, in a randomized order, with twenty healthy subjects who were exposed to experimental heat pain stimulation applied to the right forearm using a Contact Heat-Evoked Potential Stimulator. While in one session TVNS was administered bilaterally to the concha auriculae with maximal, non-painful intensity, the stimulation device was switched off in the other session (placebo condition). Pain thresholds were measured before and after each session. Heat stimulation elicited fMRI activation in cerebral pain processing regions. Activation magnitude in the secondary somatosensory cortex, posterior insula, anterior cingulate and caudate nucleus was associated with heat stimulation without TVNS. During TVNS, this association was only seen for the right anterior insula. TVNS decreased fMRI signals in the anterior cingulate cortex in comparison with the placebo condition; however, there was no relevant pain reducing effect over the group as a whole. In contrast, TVNS comp...Continue Reading

References

Jan 1, 1986·Annual Review of Neuroscience·G E AlexanderP L Strick
May 20, 1999·Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine·L R BecerraD Borsook
Aug 31, 1999·Philosophical Transactions of the Royal Society of London. Series B, Biological Sciences·M Ingvar
Jan 29, 2000·Nature Neuroscience·A D CraigE M Reiman
Feb 9, 2000·Child's Nervous System : ChNS : Official Journal of the International Society for Pediatric Neurosurgery·E C Ventureyra
May 29, 2000·Trends in Cognitive Sciences·G BushM I Posner
Nov 9, 2000·Neurology·A KirchnerH O Handwerker
Feb 9, 2002·Clinical Anatomy : Official Journal of the American Association of Clinical Anatomists & the British Association of Clinical Anatomists·Elmar T Peuker, Timm J Filler
Mar 30, 2004·Annals of Neurology·Stéphane LehéricyDae-Shik Kim
Sep 28, 2004·Human Brain Mapping·Silke AndersNiels Birbaumer
Jun 14, 2005·Neuropsychologia·Lionel NaccacheJean-Claude Willer
Jun 28, 2005·European Journal of Pain : EJP·A Vania ApkarianJon-Kar Zubieta
Dec 26, 2006·Expert Review of Neurotherapeutics·Mark S GeorgeE Baron Short
Jul 8, 2008·Biomedizinische Technik. Biomedical Engineering·Stefan DietrichRalf Ringler
Mar 14, 2009·Somatosensory & Motor Research·W FreundA P Wunderlich
May 15, 2009·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Frank SeifertChristian Maihöfner
Nov 3, 2010·The Journal of Clinical Investigation·Michael H OssipovFrank Porreca
Dec 2, 2011·Human Brain Mapping·Emma G Duerden, Marie-Claire Albanese
May 10, 2012·Pain Medicine : the Official Journal of the American Academy of Pain Medicine·Vitaly NapadowAjay D Wasan
Apr 23, 2013·Brain Stimulation·Bianca LeutzowTaras I Usichenko
May 10, 2013·European Journal of Pain : EJP·K GrosenA M Drewes
Jun 19, 2013·Cephalalgia : an International Journal of Headache·Rita LickteigBernd Kordass
Jun 20, 2013·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·Nils B KroemerMichael N Smolka
May 29, 2014·Neurological Sciences : Official Journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology·M RomoliE Fornari

❮ Previous
Next ❯

Citations

Jul 18, 2020·Nature Communications·Monja P NeuserNils B Kroemer
Nov 6, 2020·Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association·Marie Hilderman, Annette Bruchfeld
Dec 23, 2020·Neuromodulation : Journal of the International Neuromodulation Society·Yu WangPeijing Rong
Jun 24, 2021·Neuromodulation : Journal of the International Neuromodulation Society·Mikołaj Tytus Szulczewski
Dec 24, 2021·Expert Review of Medical Devices·Lei WangPeijing Rong

❮ Previous
Next ❯

Software Mentioned

SPSS
MATLAB
SPM8
Automated atlas
PATHWAY
PATHWAY Pain and Sensory Evaluation System
PATHWAY System
- Statistics
ALE

Related Concepts

Related Feeds

Basal Ganglia

Basal Ganglia are a group of subcortical nuclei in the brain associated with control of voluntary motor movements, procedural and habit learning, emotion, and cognition. Here is the latest research.

Barrel cortex

Here is the latest research on barrel cortex, a region of somatosensory and motor corticies in the brain, which are used by animals that rely on whiskers for world exploration.