Preliminary gas chromatography with mass spectrometry determination of 3,5-dimethoxyphenol in biological specimens as evidence of taxus poisoning

Journal of Analytical Toxicology
R FroldiV Gambaro

Abstract

Taxus baccata is a widely distributed yew often associated with cases of fatal intoxication, which is related to the high amounts of cardiotoxic alkaloids, taxine A and taxine B, contained in its leaves. In this paper, a case of Taxus fatal poisoning, hypothesized by the forensic autopsy, has been confirmed by the application of both gas chromatography-mass spectrometry (GC-MS) and liquid chromatography-tandem mass spectrometry (LC-MS-MS) techniques. A GC-MS method was used for the determination of the derivatized 3,5-dimethoxyphenol, a cyanogenic aglylactone considered as a marker of Taxus poisoning, being present in all species of Taxus. The detection by LC-MS-MS of taxine B and isotaxine B in the biological specimens confirmed the absorption of cardiotoxic alkaloids and allowed to established the cause of death as the ingestion of Taxus baccata leaves.

Citations

Dec 26, 2012·Forensic Science International : Synergy·Thomas GroboschTorsten Binscheck
Jul 21, 2016·Clinical Toxicology : the Official Journal of the American Academy of Clinical Toxicology and European Association of Poisons Centres and Clinical Toxicologists·Ann M ArensKent Olson
Jan 25, 2018·The Annals of Pharmacotherapy·Alexander W Labossiere, Dennis F Thompson
Aug 19, 2017·Environmental Technology·Karthikeyan VelayuthamSivanesan Subramanian
Nov 16, 2021·Journal of Forensic Sciences·Elizabeth W L Brooks-LimAaron M Shapiro

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