PMID: 6413432Oct 15, 1983Paper

Preliminary identification of a tumor-associated glycoprotein in bilharzial bladder cancer urine

International Journal of Cancer. Journal International Du Cancer
G I Higashi, A M El-Asfahani

Abstract

A tumor-associated antigen was preliminarily identified in urine from bilharzial (squamous-cell carcinoma) bladder cancer patients. Monospecific rabbit antisera were made by immunization with concentrated bladder cancer urine and exhaustive absorption with insoluble normal human serum and urine. The urine tumor-associated antigen was identical to an antigen from 3M KCl bladder tumor extract by immunodiffusion. The antigen in urine was found in nine of 10 bladder cancer patients and was absent from normal urine and serum by immunodiffusion and immunoelectrophoresis. The antigen was a concanavalin-A-binding glycoprotein which was anodal on immunoelectrophoresis. It was stable up to 2 years at -20 degrees C and did not cross-react with carcinoembryonic antigen or with Schistosoma haematobium antigens.

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Citations

Nov 1, 1990·British Journal of Addiction·C Turner, P Anderson
Nov 1, 1993·Addiction·P AndersonP Wallace

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