Preliminary investigation of environmental prevalence of Clostridium difficile affecting inpatients in a north Indian hospital

Indian Journal of Medical Microbiology
C Vaishnavi, M Singh

Abstract

A preliminary study was conducted to see the prevalence of Clostridium difficile in patients and their environment in a tertiary care hospital. Seventy-nine fecal specimens from hospitalized patients, 176 swab samples from beds and 48 from hands of hospital personnel were investigated. Sixty-three patients received antibiotics and 14 proton pump inhibitors. Abdominal pain was observed in 16 patients with fever in 15 of them. C. difficile culture was positive in 12.6% patients at initial sampling but none were toxin-positive. Eight patients developed diarrhea and five were both culture and toxin-positive. Fifty-one percent of bed swab samples and 62.5% of hand swab samples were culture positive. Similarly 8.5% of bed swab samples and 4.2% of hand swab samples were positive for toxins A and B. The environmental cross-infection between patients and carriage by hospital personnel are plausible sources of C. difficile infection and spread in our hospital.

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Citations

Jul 3, 2013·Antimicrobial Resistance and Infection Control·Deirdre A CollinsThomas V Riley
Feb 14, 2014·Osong Public Health and Research Perspectives·Monali P Mishra, Rabindra N Padhy
Jan 7, 2018·Journal of Clinical Microbiology·G A RoldanN R Pollock
Aug 11, 2017·Tropical Medicine & International Health : TM & IH·Joseph D ForresterSherry M Wren
Jun 10, 2021·Clinical Pathology·Canna J GhiaGautam S Rambhad

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